Diamondbacks vs Cardinals Prediction 5/25/25 MLB Picks Today

The Arizona Diamondbacks are visiting the St. Louis Cardinals on Sunday, May 25^th at the Busch Stadium in the third game of this series, with the Cardinals having a 2-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Diamondbacks vs Cardinals Prediction. We will examine:

The St. Louis Cardinals recent form and player performance

The Arizona Diamondbacks recent form and player performance

Recent betting trends and streaks involving the Saint Louis Cardinals

Recent betting trends and streaks involving the Arizona Diamondbacks

Recent betting trends in games played between the Arizona Diamondbacks vs Saint Louis Cardinals

A summary that ties it all together and produces a favorable betting outcome for the Arizona Diamondbacks vs Saint Louis Cardinals game

St. Louis Cardinals Preview

The St. Louis Cardinals have a 29-23 record this season and are sitting on the second place of the NL Central. The Cardinals have a 18-8 home record and are 27-24 in over/under They are coming off a 6-5 home victory over the Diamondbacks, and have back-to-back wins. They are playing the Rangers and the Orioles next.

The Cardinals have a .261 batting average this season, .333 OBP and .400 Slugging percentage. Saint Louis’ pitching staff has a 3.74 ERA and 1.22 WHIP. Brendan Donovan leads the Cardinals with 62 hits and a team-high .320 batting average, while Wilson Contreras leads the team in RBI, with 28.

Sonny Gray (R) will take the mound for the Cardinals, and he has a 5-1 record, 4.02 ERA and 1.13 WHIP. He has been better at home with a 3.05 ERA in seven home starts, and he has two shutout performance in his last two starts, both of them at home. In his only start against the Dbacks back in 2015, he gave up 2 runs in 6.1 innings of work.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 26-26 record this season and are sitting on the 4^th place of the NL West. The Diamondbacks have a 13-13 road record and are 22-26 in over/under They are coming off a 5-6 road defeat by the Cardinals, and have four consecutive losses. Under is 3-1 in their last 4 games, and are playing the Pirates and the Nationals next.

The Diamondbacks have a .255 batting average this season, .333 OBP and .449 slugging percentage. Arizona’s pitching staff has a 4.68 ERA and 1.32 WHIP. Corbin Carroll leads the Diamondbacks with 58 hits and a team-high 14 home runs, while Geraldo Perdomo is the team’s best hitter with a .309 batting average. Eugenio Suarez leads the team in RBI, with 38.

Brandon Pfaadt (R) will take the mound for the Diamondbacks, and he has a 7-3 record, 3.81 ERA and 1.24 WHIP. He has been weaker on the road, with a 6.15 ERA across five road starts, and he has given up 3+ runs in three of his last four starts. Brandon Pfaadt with an ERA of 6.35 and 8 strikeouts in 2 appearances versus the Cardinals in his career.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last seven home games against National League opponents.
• The Diamondbacks have lost each of their last four games.
• The Cardinals have covered the run line in 12 of their last 13 games against National League opponents.
• The Diamondbacks have failed to cover the run line in four of their last five day games against National League opponents.
• The Diamondbacks have trailed after 3 innings in each of their last six day games against NL Central opponents.
• The Cardinals have led after 5 innings in three of their last four games as favorites against National League opponents.
• The Diamondbacks have lost the first inning in four of their last five day games against NL Central opponents.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won eight of their last 10 games as underdogs against NL Central opponents following a loss.
• The Cardinals have lost three of their last four games as home favorites against the Diamondbacks following a home win.
• The Diamondbacks have covered the run line in each of their last eight Sunday games as road underdogs.
• The Cardinals have failed to cover the run line in each of their last five games against the Diamondbacks following a win.
• The Diamondbacks have led after 5 innings in five of their last six games against the Cardinals.

Total Runs Facts

• Five of the Cardinals’ last six day games after playing the previous day have gone UNDER the total runs line.
• Three of the Diamondbacks’ last four games have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last six games as road underdogs against NL Central opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last four day games between the Diamondbacks and Cardinals at Busch Stadium.

Matchup/League Facts

• The Cardinals rank 29th in the league for strikeouts this season (366).
• The Cardinals rank T2nd in the league for home runs allowed this season (40).
• The Diamondbacks rank 1st in the league for doubles this season (104).
• The Diamondbacks are one of only three teams in the league to rank top 10 in both strikeouts and on-base percentage this season.

Diamondbacks vs Cardinals Prediction

The Cardinals are 4-1 in their last 5 meetings against the Diamondbacks, and under is 5-2 in their last 7 meetings. In this Diamondbacks vs Cardinals Prediction, the Cardinals are coming as -125 home favorites. The Cardinals are rightfully favored, as they have the better overall record, and have been very strong at home, while the Dbacks have been mediocre on the road.

The Cardinals are coming into this matchup in better form, and have won both games in this series, they have a better bullpen and are also better at hitting righties. Sonny Gray has been very good at home, while Brandon Pfaadt has been very weak on the road, and due to some negative regression, as he has a 6.30 expected ERA this season. All things point to a home win in this one, so take the Saint Louis Cardinals on the moneyline.