Guardians vs Blue Jays Prediction 6/25/25 MLB Picks Today

In this article, we will formulate a Guardians vs Blue Jays prediction for this MLB game on Wednesday, June 25th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 39-38 this season after they lost game one by a score of 10-6 on Tuesday. Cleveland cut the deficit to 6-4 in the seventh inning, but they allowed four runs in the eighth to seal the loss. The Guardians recorded eight hits and they committed three errors in the game, while they were led by Thomas, who went 2-4 with one home run and three RBIs in the loss. Cleveland started Allen, who allowed eight hits and three earned runs over 5.2 innings for the loss, while Allard and Gaddis combined to allow six earned runs in relief. 

Prior to this series, the Guardians won two out of three against the Athletics and two out of three against the Giants. Cleveland has lost three of their last five games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 3.91 ERA with a 1.38 WHIP and a .253 opponent batting average, while the offense has scored 292 runs with a .230 batting average and a .301 on-base percentage this season. Jose Ramirez has led Cleveland with 13 home runs and 36 RBIs, while Kyle Manzardo has added 12 home runs and 32 RBIs this year. The projected starting pitcher for Cleveland is Gavin Williams, who is 5-3 with a 3.58 ERA and a 1.42 WHIP over 75.1 innings pitched this season. 

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 42-36 this year after they won game one by a score of 10-6. Toronto was able to take a 6-1 lead in the seventh inning, but they did allow five runs late in the game, before finishing the win. The Blue Jays recorded 14 hits and they committed one error in the game, while they were led by Springer, who went 3-5 with one home run and four RBIs in the win. Toronto started Lauer, who allowed five hits and one earned run over 5.1 innings for the win, while four relievers allowed at least one earned run. 

Prior to this series, the Blue Jays lost two out of three against the White Sox, but did win two out of three against the Diamondbacks before that. Toronto has lost three of its last five games, and they are currently third in the AL East standings. The Toronto pitching staff has a 4.20 ERA with a 1.25 WHIP and a .237 opponent batting average, while their offense has scored 340 runs with a .257 batting average and a .326 on-base percentage this season. Bo Bichette has led Toronto with 11 home runs and 48 RBIs, while Vladimir Guerrero has added 10 home runs and 39 RBIs this year. The projected starting pitcher for Toronto is Max Scherzer, who is 0-0 with a 6.00 ERA and a 1.00 WHIP over 3.0 innings pitched this year. 

Why the Guardians will beat the Blue Jays

• The Guardians have won 10 of their last 11 games as underdogs against the Blue Jays following a home loss.
• The Blue Jays have lost eight of their last nine games as road favorites against the Guardians following a win.
• The Guardians have covered the run line in each of their last seven games against the Blue Jays following a loss.
• The Blue Jays have failed to cover the run line in eight of their last nine games as road favorites against the Guardians following a win.
• The Blue Jays have trailed after 3 innings in four of their last five games at Progressive Field.
• The Guardians have led after 5 innings in four of their last five games against the Blue Jays at Progressive Field.

Total Runs Facts

• Each of the Guardians’ last six games after playing the previous day have gone UNDER the total runs line.
• Each of the Blue Jays’ last five games as road favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Blue Jays’ last eight night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Guardians’ last seven home games against American League opponents.

Cleveland Guardians Player Prop Facts

• Carlos Santana has hit a home run in four of his last five appearances with his team as an underdog against the Blue Jays.
• Steven Kwan has recorded at least one hit in each of his last 11 home appearances against AL opponents that held a winning record.

Toronto Blue Jays Player Prop Facts

• George Springer has hit a home run in four of the Blue Jays’ last five road games against AL opponents that held a winning record.
• Ernie Clement has recorded a Double in each of his last five appearances against former teams.
• Ernie Clement has recorded two or more hits in each of the Blue Jays’ last eight games as favorites against AL opponents.
• Max Scherzer has recorded six or more strikeouts in 11 of his last 12 road appearances against AL Central opponents that held a winning record.

Guardians vs Blue Jays Prediction 

Toronto was able to pick up a very nice win on Tuesday night to start this series, but they have allowed at least six runs in three of their last five games. The Blue Jays are 17-20 on the road this year, while the Guardians are 19-16 at home. Cleveland is second in the AL Central standings, but they are nearly 10 games behind Detroit. The Guardians are starting Williams, who has allowed two earned runs or fewer in three of his last four starts. The Blue Jays are going with Scherzer, who hasn’t pitched since March 29th. I can’t trust Scherzer in this situation, so give me Cleveland here.