White Sox vs Diamondbacks Prediction 6/25/25 MLB Picks Today

The Arizona Diamondbacks and Chicago White Sox meet Wednesday in MLB action at Rate Field. Here’s a White Sox vs Diamondbacks Prediction. This article will include a White Sox vs Diamondbacks Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 41-38 on the year and play the Marlins, Giants, and Royals next. The Arizona Diamondbacks are batting .255 on the season, have a .331 OBP, and a .449 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.70 ERA and a 1.34 WHIP. Josh Naylor leads the Arizona Diamondbacks with 87 hits and 51 RBI, while Geraldo Perdomo and Lourdes Gurriel Jr. have combined for 147 hits and 93 RBI.

Zac Gallen gets the ball for the Arizona Diamondbacks, and he is 5-8 with a 5.60 ERA and 86 strikeouts this season. This will be Gallen’s second career game against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 25-55 on the year and play the Giants, Dodgers, and Rockies next. The Chicago White Sox are batting .219 on the season, have a .292 OBP, and a .340 slugging percentage. The Chicago White Sox pitching staff has a 4.23 ERA and a 1.40 WHIP. Miguel Vargas leads the Chicago White Sox with 67 hits and 34 RBI, while Lenyn Sosa and Chase Meidroth have combined for 116 hits and 26 RBI.

Sean Burke gets the ball for the Chicago White Sox, and he is 3-6 with a 4.50 ERA and 61 strikeouts this season. This will be Burke’s first career game against the Arizona Diamondbacks.

Why the Chicago White Sox will win

• The White Sox have won seven of their last 10 games as home underdogs following a home loss.
• The Diamondbacks have lost each of their last four day games against teams that held a losing record.
• The Diamondbacks have failed to cover the run line each of their last four day games against teams that held a losing record.
• The White Sox have covered the run line in six of their last seven day games following a home loss.
• The White Sox have led after 5 innings in three of their last four day games against National League opponents that held a winning record.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last seven games against AL Central opponents.
• The White Sox have lost each of their last six games at Rate Field.
• The Diamondbacks have covered the run line in each of their last seven day games against American League opponents following a win.
• The White Sox have failed to cover the run line in each of their last seven Wednesday games as home underdogs against National League opponents.
• The Diamondbacks have led after 5 innings in six of their last seven games against American League opponents that held a losing record.
• The White Sox have trailed after 3 innings in four of their last five games against National League opponents that held a winning record.
• The Diamondbacks have won the first inning in each of their last four games against AL Central opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit a home run in two of the White Sox’s last three day games against NL opponents that held a winning record.
• Korey Lee has recorded at least one hit in each of his last six appearances against NL opponents that held a winning record.
• Luis Robert ranks T4th in the league in Steals (22) this season.

Arizona Diamondbacks Player Prop Facts

• Zac Gallen has recorded seven or more strikeouts in three of his last four appearances against AL Central opponents.
• Ketel Marte has hit a home run in eight of the Diamondbacks’ last nine games against AL Central opponents.
• Eugenio Suarez has recorded a Double in four of his last five appearances against AL Central opponents.
• Josh Naylor has recorded at least one hit in each of his last 12 appearances.
• Zac Gallen has recorded a win in three of his last four road appearances against opponents that held a losing record.

White Sox vs Diamondbacks Prediction

We continue to fade the White Sox, and it continues to work, as this is just an awful team across the board. While Burke has been solid this season overall, he’s allowed 19 hits and 10 earned runs in his last 16 innings. Gallen has been a mess in his own right with a 5.60 ERA and 1.40 WHIP, and he’s allowed 26 hits and 16 earned runs in his last 25 innings. However, we know what Gallen is capable of when he’s right. Gallen is an all-star caliber pitcher who was top-10 in CY Young voting in 2020. Gallen won’t struggle forever. Give me the Diamondbacks and the reasonable price.