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Pirates vs Tigers Prediction 7-22-25 MLB Picks

Detroit Tigers (60-41) vs. Pittsburgh Pirates (40-61)
July 22, 2025 10:40 pm EDT
The Line: Pittsburgh Pirates +123 / Detroit Tigers -149; Over/Under: 8
(Get latest betting odds)

The Detroit Tigers and the Pittsburgh Pirates meet Tuesday in MLB action from PNC Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Pirates vs Tigers Prediction.

Starting Pitching Matchup

The Detroit Tigers will send out Casey Mize here, and Mize is 9-3 with a 3.15 ERA and 77 strikeouts this season. In his career, Mize is 1-0 with a 3.27 ERA and 6 strikeouts against the Pirates. The Pittsburgh Pirates will start Mitch Keller here, and Keller is 3-10 with a 3.48 ERA and 92 strikeouts this season. In his last five starts against the Tigers, Keller is 1-1 with a 3.67 ERA and 33 strikeouts.

Detroit Tigers Recap

The Detroit Tigers come into this game looking to bounce back from a 3-0 loss at the hands of the Pirates in Monday’s series opener to sit at 60-41 on the year. After this series, the Tigers will head home for a series against the Toronto Blue Jays.

Tigers Drop 7 Of Their Last 8

Spencer Torkelson has 78 hits along with a .233 batting average, including a team-high 21 home runs, 20 doubles, and 59 RBIs. Kerry Carpenter also has 16 home runs and 32 RBIs, while Riley Greene has 106 hits with 21 doubles, 25 home runs, and 79 RBIs, but also has a team-high 129 strikeouts this season. Dillon Dingler has 8 home runs and 36 RBIs, and Zack McKinstry’s added 14 doubles, 8 triples, 8 home runs, and 32 RBIs of his own, along with 83 hits this season. Javier Baez has added 75 hits and 13 doubles as well as 10 home runs and 39 RBIs this season.

Why the Detroit Tigers will win

  • The Pirates have lost each of their last seven home games against American League opponents following a win.
  • The Tigers have won each of their last six night games against NL Central opponents following a loss.
  • The Pirates have failed to cover the run line in each of their last seven home games against American League opponents following a win.
  • The favorites have covered the run line in each of the last six games between the Tigers and Pirates.

Detroit Tigers Player Prop Facts

  • Kerry Carpenter has hit a home run in each of the Tigers’ last two games as road favorites against NL Central opponents.
  • Matt Vierling has recorded at least one hit in each of his last nine appearances with his team as a road favorite against NL opponents.
  • Casey Mize has recorded a win in four of his last five appearances in night games against teams that held a losing record.
  • Gleyber Torres ranks 6th amongst qualified players for On Base Percentage (.388) this season.

Pittsburgh Pirates Recap

The Pittsburgh Pirates come into this game looking to add on to their win over the Tigers from Monday’s series opener to improve to 40-61 on the year. After this series, the Pirates will welcome the Arizona Diamondbacks to town.

Pirates Looking To Build Some Steam

Bryan Reynolds has 84 hits with 19 doubles, 10 home runs, and 46 RBIs while also posting 109 strikeouts so far this season. Oneil Cruz has posted a team-high 16 home runs and 39 RBIs with 30 stolen bases, while Isiah Kiner-Falefa has 79 hits with 12 doubles and 12 stolen bases. Cruz also has a team-high 121 strikeouts this season. Tommy Pham has 8 doubles and Andrew McCutchen has 80 hits with 15 doubles, and KeBryan Hayes has 80 hits with 33 RBIs and 10 stolen bases.

Why the Pittsburgh Pirates will win

  • The Pirates have won each of their last 10 home games against teams that held a winning record.
  • The Tigers have lost seven of their last eight games.
  • The Tigers have failed to cover the run line in each of their last eight games.
  • The Pirates have covered the run line in each of their last four games as home underdogs.

Pittsburgh Pirates Player Prop Facts

  • Bryan Reynolds has hit a home run in three of his last six appearances with the Pirates as home underdogs.
  • Mitch Keller has recorded five or more strikeouts in each of his last six appearances in night games against AL teams that held a winning record.
  • Bryan Reynolds has recorded at least one hit in each of the Pirates’ last 17 home games against AL Central opponents that held a winning record.
  • Mitch Keller has recorded a win in four of his last five appearances in night games against AL teams that held a winning record.
  • Bryan Reynolds has recorded a Double in three of the Pirates’ last four games as home underdogs.
  • Oneil Cruz ranks 2nd in the league in Steals (30) this season.

Total Runs Facts

  • Each of the Tigers’ last seven games as favorites against National League opponents have gone OVER the total runs line.
  • Each of the Pirates’ last five games as underdogs against the Tigers have gone OVER the total runs line.

Pirates vs Tigers Prediction

I’m siding with the under here. This may not have Paul Skenes going for the Pirates on Tuesday, but Mitch Keller is still a solid option, and I think he can have a good enough start in this game to keep Pittsburgh competitive. On the other side, Casey Mize is probably one of the better options in this Tiger rotation, and I think he can hold down what’s been a relatively weak-hitting Pirates lineup here. Give me the under.

Chris Ruffolo's Free Pick: Under 8

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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