Twins vs Athletics Prediction 8/21/25 MLB Picks Today

The Athletics and the Minnesota Twins meet Thursday in MLB action from Target Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Twins vs Athletics Prediction.

Starting Pitching Matchup

The Athletics will send out Jack Perkins for the start here and Perkins is 2-2 with a 4.28 ERA and 35 strikeouts this season. This will be Perkins’ first career start against the Minnesota Twins. The Minnesota Twins did not have a starting pitcher announced at the time that this article was posted.

Athletics Recap

The Athletics will be looking to add on to their 4-2 win over the Minnesota Twins from Wednesday’s matchup to sit at 58-70 this season. After this series, the Athletics will head on the road for a series against the Seattle Mariners.

Athletics Win 7 Of Last 10

Jacob Wilson has 115 hits, 17 doubles and a .312 batting average while Tyler Soderstrom has 121 hits with 24 doubles, 23 home runs and 74 RBIs this season. Brent Rooker has 135 hits with 30 doubles, 25 home runs and 72 RBIs but also has 124 strikeouts this season while Nick Kurtz has a team-high 25 home runs and 67 RBIs with 23 doubles. Shea Langeliers has 99 hits with 28 home runs and 60 RBIs while Lawrence Butler’s also chipped in 17 stolen bases and 27 doubles as part of his 106 hits as well as 17 home runs and 48 RBIs while also owning a team-high 146 strikeouts this season.

Why the Athletics will win

• The Twins have lost eight of their last nine day games after going to extra innings.
• The Athletics have won eight of their last nine road games against American League opponents.
• The Athletics have covered the run line in each of their last 10 road games against American League opponents.
• The Twins have failed to cover the run line in each of their last 10 day games against the Athletics at Target Field following a loss.

Athletics Player Prop Facts

• Shea Langeliers has hit a home run in four of the Athletics’ last five games against opponents that held a losing record.
• Shea Langeliers has recorded a Double in six of his last eight appearances against AL Central opponents.
• Zack Gelof has recorded at least one hit in each of his last eight appearances against AL Central opponents.
• Shea Langeliers ranks 6th amongst qualified players for Slugging Percentage (.553) this season.

Minnesota Twins Recap

The Minnesota Twins come into this game looking to bounce back from a loss at the hands of the Athletics on Wednesday to slip to 58-68 this season. After this series, the Twins will take to the road for a series against the Chicago White Sox.

Twins Lose 8 Of Their Last 11

Byron Buxton has 99 hits along with 15 doubles, a team-high 25 home runs and 61 RBIs with 18 stolen bases and 4 triples while Trevor Larnach’s chipped in 98 hits with 17 doubles, 16 home runs and 50 RBIs as well this season. Brooks Lee has contributed 93 hits with 13 doubles, 13 home runs and 53 RBIs and Matt Wallner has 16 homers and 28 RBIs as well.

Why the Minnesota Twins will win

• The underdogs have won each of the Twins’ last four games.
• The Athletics have lost four of their last five games as favorites against American League opponents following a win.
• The Twins have covered the run line in 14 of their last 15 games as underdogs against AL West opponents following a loss.
• The Athletics have failed to cover the run line in each of their last four games as favorites against AL Central opponents.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit a home run in three of his last five appearances in day games.
• Trevor Larnach has recorded at least one hit in 13 of his last 14 home appearances against AL West opponents that held a losing record.
• Byron Buxton ranks 8th amongst qualified players for Slugging Percentage (.544) this season.

Total Runs Facts

• Five of the Athletics’ last six road games after playing the previous day have gone UNDER the total runs line.
• Four of the Twins’ last five games as home underdogs have gone UNDER the total runs line.

Twins vs Athletics Prediction

I’m on the Athletics in this one. The Twins just can’t get themselves back on track and as the days go by, it’s evident that this is a Twins’ lineup that’s just playing out the string. The Athletics actually look like a team that wants to improve and wants to build something for the future, while the Twins unloaded the shelves at the trade deadline. They took no prisoners when it came to offloading starters to stockpile assets going forward. I just think that the Athletics are the better team right now, and I just want no part of the Twins in their current form, regardless of who is starting on the mound here. Give me the Athletics here.