James Madison Dukes (1-0) vs. Louisville Cardinals (1-0)
September 5, 2025 7:00 pm EDT
The Line: Louisville Cardinals -14 / James Madison Dukes +14; Over/Under: 57.5
(Get latest betting odds)
The James Madison Dukes and Louisville Cardinals meet Friday in college football action at L&N Federal Credit Union Stadium. Here’s a Louisville vs James Madison Prediction. This article will include a Louisville vs James Madison Pick.
James Madison Dukes Betting Preview
The James Madison Dukes beat Weber State, and they play Liberty and Georgia Southern next. The James Madison Dukes look to start 2-0 for a sixth straight season. Alonza Barnett III is completing 63.6 percent of his passes for 130 yards, 1 touchdown, and 0 interceptions. Michael Scott and Logan Kyle have combined for 69 receiving yards on 6 catches, while Isaiah Alston has 3 receptions.
The James Madison Dukes ground game is averaging 190 yards per contest, and George Pettaway leads the way with 99 yards on 10 carries. Defensively, James Madison is allowing 10 points and 148 yards per game. Trent Hendrick leads the James Madison Dukes with 7 tackles, DJ Barksdale has 2 pass deflections and Tyler Brown has 1 interception.
Louisville Cardinals Betting Preview
The Louisville Cardinals beat Eastern Kentucky, and they play Bolwing Green and Pitt next. Louisville looks for its fourth straight 2-0 start. Miller Moss is completing 68 percent of his passes for 223 yards, 1 touchdown, and 1 interception. Chris Bell and Caullin Lacy have combined for 125 receiving yards on 9 catches, while Kris Hughes has 3 receptions.
The Louisville Cardinals ground game is averaging 163 yards per contest, and Isaac Brown leads the way with 126 yards and 2 touchdowns. Defensively, Louisville is allowing 17 points and 50 yards per game. Jordan Guerad leads the Louisville Cardinals with 6 tackles, Clev Lubin has 2 sacks and Rene Konga has 1 pass deflection.
Louisville Cardinals Player Prop Facts
- Heading into Week 2, Keyjuan Brown ranks T1st amongst qualified players for catch rate (100.0%) this season.
James Madison Dukes Player Prop Facts
- George Pettaway has recorded 50+ rushing yards in 10 consecutive games – equal-longest streak in the FBS, heading into Week 2.
Louisville vs James Madison Prediction
Louisville is the more talented team and is going to be favored for obvious reasons, but this is a lot of points for a Cardinals side that’s breaking in new players at key positions. Louisville has failed to cover three of its last five games as a double-digit favorite, which includes an outright loss last season to Stanford.
James Madison has a difference maker at quarterback and has covered four of its last six games as a double-digit underdog. Let’s not forget last year’s upset win over North Carolina, where it dropped 70 points. I’ll take the two free touchdowns.
