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Orioles vs Dodgers Prediction 9/5/25 MLB Picks Today

LA Dodgers (78-62) vs. Baltimore Orioles (64-76)
September 5, 2025 7:05 pm EDT
The Line: Baltimore Orioles 138 / LA Dodgers -169; Over/Under: 8.5
(Get latest betting odds)

In this article we will formulate an Orioles vs Dodgers prediction for this MLB game on Friday, September 5th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 64-76 this year after they won all three against San Diego by scores of 4-3, 6-2, and 7-5. In their game three win, Baltimore scored the first seven runs in the game, but failed to score in the last six innings and nearly blew the lead. The Orioles recorded eight hits in the game and they were led by Cowser, who went 1-5 with one home run and three RBIs in the win. Baltimore started Povich, who allowed seven hits and four earned runs over 5.0 innings for the win, while Akin allowed one earned run in relief. 

Prior to that series, the Orioles lost two out of three against the Giants and all four against the Red Sox. Baltimore has won four of their last five games and they are currently last in the AL East standings. The Baltimore pitching staff has a 4.70 ERA with a 1.38 WHIP and a .262 opponent batting average, while their offense has scored 612 runs with a .242 batting average and a .308 on base percentage this season. Jackson Holliday has led Baltimore with 16 home runs and 52 RBIs, while Gunnar Henderson has added 16 home runs and 61 RBIs this year. The projected starting pitcher for Baltimore is Dean Kremer, who is 9-10 with a 4.52 ERA and a 1.27 WHIP over 155.1 innings pitched this year. 

Los Angeles Dodgers Betting Preview

The Los Angeles Dodgers are 78-62 this season after they lost all three against Pittsburgh by scores of 7-9, 0-3, and 3-5. In their game three loss, Los Angeles was dominated by Skenes for most of the game, but they did manage three runs in the ninth to make it look closer than it was. The Dodgers recorded eight hits and they committed one error in the game, while they were led by Betts, Pages, and Rojas, who all had one RBI in the loss. LA started Snell, who allowed nine hits and five earned runs over 5.0 innings for the loss, while Henriquez, Yates, and Dreyer finished the game in relief. 

Prior to that series, the Dodgers lost two out of three against the Diamondbacks, but did win all three against the Reds before that. Los Angeles has lost five of their last six games and they are currently first in the NL West standings. The Los Angeles pitching staff has a 4.13 ERA with a 1.29 WHIP and a .241 opponent batting average, while their offense has scored 710 runs with a .252 batting average and a .329 on base percentage this season. Shohei Ohtani has led LA with 46 home runs and 87 RBI’s, while Andy Pages has added 24 home runs and 79 RBIs this year. The projected starting pitcher for Los Angeles is Tyler Glasnow, who is 1-3 with a 3.41 ERA and a 1.11 WHIP over 68.2 innings pitched this season. 

Why the Orioles will beat the Dodgers

  • The Dodgers have lost each of their last four games as favorites against American League opponents.
  • The underdogs have won five of the Dodgers’ last six games.
  • The Dodgers have failed to cover the run line in each of their last six games.
  • The underdogs have covered the run line in 14 of the Orioles’ last 16 games at Oriole Park at Camden Yards.
  • The Orioles have won the first inning in five of their last six night games against NL West opponents.
  • The Dodgers have trailed after 3 innings in each of their last four road games.
  • The Dodgers have trailed after 5 innings in five of their last six road games.

Why the Dodgers will beat the Orioles

  • The Dodgers have won each of their last 11 Friday games against AL East opponents.
  • The Orioles have lost seven of their last eight home games.
  • The Dodgers have covered the run line in each of their last six night games against AL East opponents following a loss.
  • The Orioles have failed to cover the run line in 11 of their last 13 home games against NL West opponents following a win.
  • The Orioles have lost the first inning in three of their last four home games.
  • The Dodgers have led after 3 innings in each of their last four night games against the Orioles.
  • The Dodgers have led after 5 innings in four of their last five night games against AL East opponents.

Total Runs Facts

  • Each of the Dodgers’ last six road games against AL East opponents have gone UNDER the total runs line.
  • Ten of the Orioles’ last 11 home games against NL West opponents have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last eight night games against NL West opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Dodgers’ last eight road games against American League opponents.

Baltimore Orioles Player Prop Facts

  • Ryan Mountcastle has recorded at least one hit in each of his last seven appearances against NL opponents.
  • Dean Kremer has recorded five or more strikeouts in seven of his last eight home appearances.
  • Tyler O’Neill has hit a home run in each of his last four home appearances against NL West opponents.
  • Dylan Carlson has recorded a Double in each of his last three home appearances.

Los Angeles Dodgers Player Prop Facts

  • Shohei Ohtani has hit a home run in four of the Dodgers’ last five games against AL opponents.
  • Tyler Glasnow has recorded seven or more strikeouts in each of his last seven road appearances against AL East opponents that held a losing record.
  • Miguel Rojas has recorded at least one hit in each of his last eight road appearances against opponents that held a losing record.
  • Freddie Freeman has recorded a Double in three of his last four appearances against the Orioles.
  • Tyler Glasnow has recorded a win in four of his last five appearances against AL opponents that held a losing record.

Orioles vs Dodgers Prediction 

Los Angeles may have one of the best records in the MLB this year, but they are struggling right now, as their lead is shrinking in the West. The Dodgers are 33-36 on the road this season, while the Orioles are 31-37 at home. Baltimore is coming off of a nice sweep of the Padres and they are starting Kremer, who has allowed 13 earned runs and 16 hits in his last two starts. LA is going with Glasnow, who has allowed three earned runs or fewer in five straight outings. I want to take the Dodgers, but they have looked awful, so I will side with the over, as Kremer has really struggled. 

David Racey's Free Pick: Over 8.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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