Giants vs Cardinals Prediction 9/22/25 MLB Picks Today

The St. Louis Cardinals and San Francisco Giants meet Monday in MLB action at Oracle Park. Here’s a Giants vs Cardinals Prediction. This article will include a Giants vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 76-80 on the year and play the Cubs next. The St. Louis Cardinals are batting .245 on the season, have a .315 OBP, and a .378 slugging percentage. The St. Louis Cardinals pitching staff has a 4.23 ERA and a 1.32 WHIP. Alec Burleson leads the St. Louis Cardinals with 138 hits and 66 RBI, while Brendan Donovan and Willson Contreras have combined for 253 hits and 128 RBI.

Michael McGreevy gets the ball for the St. Louis Cardinals, and he is 7-3 with a 4.08 ERA and 53 strikeouts this season. McGreevy is 1-1 with a 5.25 ERA and 9 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview

The San Francisco Giants are 77-79 on the year and play the Rockies next. The San Francisco Giants are batting .234 on the season, have a .311 OBP, and a .384 slugging percentage. The San Francisco Giants pitching staff has a 3.85 ERA and a 1.30 WHIP. Heliot Ramos leads the San Francisco Giants with 152 hits and 62 RBI while Jung Hoo Lee and Willy Adames have combined for 269 hits and 135 RBI.

Justin Verlander gets the ball for the San Francisco Giants, and he is 3-10 with a 3.75 ERA and 127 strikeouts this season. Verlander is 3-1 with a 4.00 ERA and 25 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals @ San Francisco Giants Betting Trends: September 22, 2025

• Probable Starting Pitcher: Justin Verlander      Record this season: 3-10      ERA: 3.75
• Home Record: 2-6
• Last 5 against Cardinals: 1-0

Why the San Francisco Giants will win

• The Cardinals have lost each of their last six road games against NL West opponents following a win.
• The Giants have won seven of their last eight night games against the Cardinals following a win.
• The Cardinals have failed to cover the run line in each of their last seven games against NL West opponents following a win.
• The Giants have covered the run line in six of their last seven night games against teams that held a losing record.
• The Giants have won the first inning in five of their last six night games at Oracle Park.
• The Giants have led after 5 innings in seven of their last eight night games against National League opponents that held a losing record.
• The Cardinals have trailed after 3 innings in each of their last six road games against NL West opponents that held a losing record.

• Probable Starting Pitcher: Michael McGreevy      Record this season: 7-3      ERA: 4.08
• Road Record: 4-0
• Last 5 against Giants: 1-1

Why the St. Louis Cardinals will win

• The Giants have lost each of their last six games as favorites against the Cardinals following a road win.
• The Cardinals have won four of their last five games as underdogs against the Giants.
• The Cardinals have covered the run line in each of their last seven games as underdogs against the Giants.
• The Giants have failed to cover the run line in each of their last six games as home favorites against NL Central opponents following a win.
• The Cardinals have led after 5 innings in six of their last seven games as underdogs.
• The Cardinals have led after 3 innings in six of their last seven games as underdogs.

Total Runs Facts

• Seven of the Giants’ last eight home games after playing the previous day have gone OVER the total runs line.
• Each of the Cardinals’ last four games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Giants’ last eight night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cardinals’ last seven games against NL West opponents.

San Francisco Giants Player Prop Facts

• Jung Hoo Lee has recorded at least one hit in each of his last 10 appearances in night games against teams that held a losing record.
• Rafael Devers has hit a home run in five of his last nine appearances against the Cardinals.
• Matt Chapman has recorded at least one Double in four of the Giants’ last five games as favorites against the Cardinals.
• Justin Verlander has recorded five or more strikeouts in eight of his last nine home appearances.

St. Louis Cardinals Player Prop Facts

• Masyn Winn has recorded at least one hit in each of his last 13 road appearances against NL West opponents that held a losing record.
• Willson Contreras has hit a home run in three of the Cardinals’ last four road games against opponents that held a losing record.
• Willson Contreras has recorded a Double in each of the Cardinals’ last three road games against NL West opponents that held a losing record.
• Victor Scott II ranks T10th in the league in Steals (33) this season.

Matchup/League Facts

• The Giants rank 1st in the league for home runs allowed this season (136).
• The Giants rank 29th in the league for steals this season (66).
• The Cardinals rank 30th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1161).

Giants vs Cardinals Prediction

The Cardinals haven’t won two straight games since September 7 and McGreevy is due for a stinker after solid outings against the Reds and Mariners. Verlander has been a shell of himself for much of the season, but he’s allowed 13 hits and 1 run in his last 25 innings. The Cards and Giants are also fighting for their playoff lives, and I’d give the edge to the home team. Verlander, a Hall of Famer, is no stranger to stepping up in big moments. It’s do or die for these clubs with a week left in the season. Give me the Giants.