Guardians vs Rangers Prediction 9/26/25 MLB Picks Today
Texas Rangers (80-79) vs. Cleveland Guardians (86-73)
September 26, 2025 7:10 pm EDT
The Line: Cleveland Guardians -151 / Texas Rangers +124; Over/Under: 7.5
(Get latest betting odds)
The Texas Rangers and the Cleveland Guardians meet Friday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Guardians vs Rangers Prediction.
Starting Pitching Matchup
The Texas Rangers will send out Jack Leiter for the start here and Leiter is 9-10 with a 3.92 ERA and 138 strikeouts this season. In his career, Leiter is 1-1 with a 6.23 ERA and 11 strikeouts against the Guardians. Slade Cecconi will get the nod for the Guardians here and Cecconi is 7-6 with a 4.15 ERA and 106 strikeouts this season. This will be Cecconi’s second career start against the Rangers.
Texas Rangers Recap
The Texas Rangers come into this game looking to rebound from a 4-0 loss at the hands of the Minnesota Twins last time out to slip to 80-79 this season.
Rangers Looking To Finish Season With Positive Showing
Corey Seager has 103 hits including 21 home runs and 50 RBIs while Adolis Garcia has 113 hits with 28 doubles, 18 home runs, 74 RBIs and 13 stolen bases. Josh Jung has 117 hits with 21 doubles, 14 home runs and 60 RBIs while Wyatt Langford has 118 hits with 25 doubles, 22 home runs, 62 RBIs and 22 stolen bases and Jonah Heim has 11 homers and 43 RBIs. Josh Smith has chipped in 124 hits with 23 doubles, 10 home runs and 35 RBIs with 12 stolen bases and Marcus Semien’s added 108 hits with 16 doubles, 15 homers and 62 RBIs but has 93 strikeouts this season.
Why the Texas Rangers will win
- The underdogs have won seven of the Rangers’ last eight games.
- The Guardians have lost four of their last five Friday games as home favorites against AL West opponents.
- The Rangers have covered the run line in each of their last nine Friday games as road underdogs.
- The Guardians have failed to cover the run line in four of their last five games as favorites following a loss.
Texas Rangers Player Prop Facts
- Josh Jung has recorded at least one hit in each of the Rangers’ last seven games against AL opponents that held a winning record.
- Josh Jung has recorded at least one Double in four of the Rangers’ last five road games against AL opponents.
- Corey Seager has hit a home run in each of his last two appearances.
Cleveland Guardians Recap
The Cleveland Guardians come into this game looking to rebound from a 4-2 loss at the hands of the Detroit Tigers last time out to sit at 86-73 this season.
Guardians Looking To Win AL Central Title
Steven Kwan has 169 hits as part of a .275 batting average and 11 home runs, 29 doubles and 56 RBIs. Kyle Manzardo has 107 hits with 18 doubles, 2 triples, 26 home runs and 68 RBIs as well this year. Gabriel Arias has 24 doubles but also 157 strikeouts and Manzardo has 132 strikeouts so far this season. Arias has also added 11 home runs and 53 RBIs and Jose Ramirez has chipped in 30 home runs and 85 RBIs with 40 stolen bases as well.Â
Why the Cleveland Guardians will win
- The Guardians have won each of their last nine home games against the Rangers following a home loss.
- The Rangers have lost nine of their last 10 games.
- The Guardians have covered the run line in each of their last nine home games against the Rangers following a home loss.
- The Rangers have failed to cover the run line in nine of their last 10 games.
Cleveland Guardians Player Prop Facts
- Jose Ramirez has hit a home run in three of the Guardians’ last five games as home favorites against AL West opponents.
- Jose Ramirez has recorded at least one hit in each of the Guardians’ last eight games.
- Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
- Jose Ramirez ranks 3rd in the league in Steals (40) this season.
Total Runs Facts
- Each of the Guardians’ last eight home games after playing the previous day have gone UNDER the total runs line.
- Each of the Rangers’ last five games have gone UNDER the total runs line.
Guardians vs Rangers Prediction
I’m on the Guardians here. I just think that the motivation has to count for something for the Guardians, who have been playing some of the best baseball in the month of September out of any team in the MLB. The Rangers had some fight down the stretch, but ultimately ran out of gas, and I think that Texas is just up against it and playing out the string in this series. Give me Cleveland here.

