USC vs Michigan Prediction Football Picks Today 10/11/25

In this article we will formulate a USC vs Michigan prediction for this College Football game on Saturday, October 11th at the Los Angeles Memorial Coliseum in Los Angeles, California. Let’s take a look at the prediction for this week 7 matchup. 

USC Trojans Betting Preview

The USC Trojans are 4-1 (2-1) this year after they lost to Illinois by a score of 34-32 in their last game. USC trailed 24-10 in the third quarter, but they took a 32-31 lead with about two minutes left, before losing on a last second field goal. The Trojans were out gained by a total of 502-490, went 8-14 on third downs, and tied the turnover battle at two in the game. Jayden Maiava went 30-43 for 364 yards, two touchdowns, and one interception, while Waymond Jordan rushed 20 times for 94 yards and two scores. Makai Lemon led the receivers with 11 receptions for 151 yards and two touchdowns in the loss. The USC defense recorded one sack and two tackles for loss in the game. 

Prior to that tough loss, USC started the season with wins over Michigan State, Purdue, Georgia Southern, and Missouri State. The Trojans are averaging 48.4 points per game with 338.0 passing yards and 227.0 rushing yards per game, while they are allowing 23.0 points against per game this season. Jayden Maiava has completed 70.5% of his passes for 1,587 yards, 11 touchdowns, and one interception, while Makai Lemon has caught 35 passes for 589 yards and five scores. Waymond Jordan has led the rushing attack with 77 carries for 537 yards and five touchdowns this year. 

Michigan Wolverines Betting Preview

The Michigan Wolverines are 4-1 (2-0) this season after they defeated Wisconsin by a score of 24-10 last week. Michigan trailed 7-0 early in the game, but they scored the next 24 points to pull away with a relatively easy victory. The Wolverines out gained Wisconsin by a total of 445-252, went 5-12 on third downs, and won the turnover battle by a margin of 1-0 in the game. Bryce Underwood went 19-28 for 270 yards and one touchdown, while Justice Haynes rushed 19 times for 117 yards and two scores. Donaven McCulley led the receivers with six catches for 112 yards and one touchdown in the game. The Michigan defense recorded one sack and three tackles for loss in the victory. 

Prior to that game, Michigan defeated Nebraska and Central Michigan, lost to Oklahoma, and defeated New Mexico. The Wolverines are averaging 34.0 points per game with 200.6 passing yards and 237.8 rushing yards per game, while they are allowing 16.2 points against per game this season. Bryce Underwood has completed 59.2% of his passes for 1,003 yards, three touchdowns, and one interception, while Donaven McCulley has 19 receptions for 309 yards and one score. Justice Haynes has led the ground game with 654 yards and eight touchdowns on 85 carries this season. 

Why the USC Trojans will win

• The favorite has won each of USC’s last nine games at United Airlines Field at the Los Angeles Memorial Coliseum.
• USC has covered the spread in seven of its last eight games as a favorite in California.
• The team ranked 15th in the AP Poll has failed to cover the spread in three of its last four games.
• USC has won the first half in three of its last four games against conference opponents.
• USC has won the first quarter in three of its last four home games against conference opponents.

Why the Michigan Wolverines will win

• Michigan has won 39 of its last 40 games against non-AP-ranked teams.
• USC has lost each of its last five games as a favorite against AP-ranked teams.
• USC has failed to cover the spread in each of its last five games as a favorite against AP-ranked teams.
• Michigan has covered the spread in four of its last five games against conference opponents.
• Michigan has won the first half in 32 of its last 41 games against conference opponents.

Total Points Facts

• Each of USC’s last nine games as a favorite against AP-ranked teams have gone OVER the total points line.
• Each of Michigan’s last seven road games against non-AP-ranked teams have gone OVER the total points line.

Matchup/League Facts

• USC ranks T1st among FBS teams for H2 points per game this season (23.6).
• USC ranks 2nd among FBS teams for yards per game this season (565.0).
• Michigan ranks 135th among FBS teams for 4th down conversion percentage this season (20.0).
• Michigan ranks 7th among FBS teams for rushing yards allowed per game this season (77.4).

USC vs Michigan Prediction 

USC comes into this matchup after a bye week, but they lost a very tough game on the road prior to the bye. The Trojans have allowed 63 points in their last two games, which is way too many, but their offense has been elite through five games. Michigan made too many mistakes against Wisconsin last week and while they are also 4-1, they have not been very convincing. The Wolverines have a very good defense from a talent perspective and they need to slow down USC, as I don’t know if Michigan has the offensive firepower to compete in a shootout. This should be one of the better games to watch this weekend and I think we will see plenty of points, so give me the over here. 

David Racey is 58-44 (57%) in College Football this season and is one of the top College Football Handicappers on the site. Click here for his premium plays for the week!