UTSA vs South Florida Prediction 11/6/25 College Football Picks Today

In this article, we will formulate a UTSA vs South Florida Prediction for this College Football Week 11 game on Thursday, November 6^th. Let’s take a look at the prediction for this College Football matchup.

South Florida Bulls Preview

South Florida has a 6-2 record this season and is sitting 4th in the American. They are 6-2 ATS, 5-3 in Over/Under and have a 4-0 home record and a 2-2 away record. South Florida is coming off a 31-34 road loss against Memphis and will face Navy, UAB and Rice next.

Offensively, South Florida averages 40.4 points per game, ranking 6th in the nation, while defensively, they allow 24.4 points per game, which is 70th. South Florida averages 487.0 total yards per game (261.5 passing and 225.5 rushing), while allowing 387.3 total yards per game (114.9 rushing and 272.4 passing).

Byrum Brown leads South Florida with 1,964 passing yards with 62.9% completed passes and 17 touchdowns. Nykahi Davenport leads the team in rushing yards with 303, while Keshaun Singleton has a team-high 29 receptions for 451 receiving yards. Defensively, Mac Harris has a team-high 69 total tackles (37 of them solo), while Mac Harris leads the team in sacks, with 5.5, and Jarvis Lee leads the team in interceptions, with 2.

UTSA Roadrunners Preview

UTSA has a 4-4 record this season and is sitting 7th in the American. They are 4-4 ATS, 6-2 in Over/Under and have a 3-1 home record and a 1-3 away record. UTSA is coming off a 48-26 home win against Tulane and will face Charlotte, East Carolina and Army next.

Offensively, UTSA averages 34 points per game, ranking 34th in the nation, while defensively, they allow 30.2 points per game, which is 109th. UTSA averages 402.1 total yards per game (223.9 passing and 178.3 rushing), while allowing 401.6 total yards per game (148.3 rushing and 253.4 passing).

Owen McCown leads UTSA with 1,680 passing yards with 67.5% completed passes and 17 touchdowns. Robert Henry leads the team in rushing yards with 955, while Devin McCuin has a team-high 43 receptions for 460 receiving yards. Defensively, Shadrach Banks has a team-high 53 total tackles (31 of them solo), while Nnanna Anyanwu leads the team in sacks, with 5.0, and Shadrach Banks leads the team in interceptions, with 2.

UTSA Roadrunners @ South Florida Bulls Betting Trends: Week 11

South Florida Bulls Player Prop Facts

• Jeremiah Koger has recorded 75+ receiving yards in four consecutive games – equal-longest streak in the FBS, heading into Week 11.

UTSA Roadrunners Player Prop Facts

• Heading into Week 11, AJ Wilson leads the American Conference for yards per reception (22.0) this season.

Matchup/League Facts

• South Florida ranks 1st among FBS teams for H2 points per game this season (22.6).
• South Florida has averaged 51.8 points over its last five games – most in the FBS over that span.
• UTSA ranks T134th among FBS teams for Q3 opponent points per game this season (10.9).
• UTSA ranks 132nd among FBS teams for H2 opponent points per game this season (18.8).

UTSA vs South Florida Prediction

In their only previous meeting back in 2023, UTSA won 49-21 at home.

In this UTSA vs South Florida Prediction, South Florida is coming as -14-point home favorites, with the total set at 68.5 points. South Florida has a better overall record and have been perfect at home with a 4-0 record. They are 4-1 both straight up and against the spread in their last 5 games and are better both offensively and defensively than UTSA, having the 6^th-best offense in the country and winning by an average of 16 points per game. I expect the hosts to get away with a comfortable win, so take South Florida and lay the -14 at home.