Brewers vs White Sox Prediction 3/28/26 MLB Picks Today

In this article we will formulate a Brewers vs White Sox prediction for this MLB game on Saturday, March 28th at American Family Field in Milwaukee, Wisconsin. Let’s take a look at the prediction for this MLB matchup. 

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 1-0 this season after they won game one by a score of 14-2 on Thursday afternoon. Milwaukee trailed 1-0 early in the game, but they scored four runs in the second inning and never looked back in the blowout win. The Brewers recorded 12 hits in the game and they were led by Contreras and Bauers, who both had three RBIs. Misiorowski allowed two hits and one earned run over 5.0 innings for the win, while Woodford allowed one hit and one earned run in one inning of relief. 

Last season, Milwaukee had a 3.58 ERA with a 1.23 WHIP and a .230 opponent batting average, while they scored 806 runs with a .258 batting average and a .332 on base percentage. Christian Yelich led the team with 29 home runs and 103 RBIs, while Brice Turang added 18 home runs and 81 RBIs. The projected starting pitcher for Milwaukee is Chad Patrick, who went 3-8 with a 3.53 ERA and a 1.28 WHIP over 119.2 innings pitched last season. 

Chicago White Sox Betting Preview

The Chicago White Sox are 0-1 this year after they were blown out in game one on Thursday. Chicago led 1-0 in the top of the first inning, but they failed to score again until the ninth and their pitching fell apart in the ugly loss. The White Sox recorded four hits and they committed one error in the game, while Meidroth and Murakami both had one RBI. Smith allowed three hits and three earned runs over 1.2 innings for the loss, while Hicks and Paez each allowed three earned runs in relief. 

Last year, Chicago had a 4.26 ERA with a 1.36 WHIP and a .248 opponent batting average, while they scored 647 runs with a .232 batting average and a .302 on base percentage. Lenyn Sosa led the team with 22 home runs and 75 RBIs, while Andrew Benintendi added 20 home runs and 63 RBIs last year. The projected starting pitcher for Chicago is Sean Burke, who went 4-11 with a 4.29 ERA and a 1.45 WHIP over 134.1 innings pitched last year. 

Why the Milwaukee Brewers will win

• The White Sox have lost each of their last 10 games against NL Central opponents following a road loss.
• The Brewers have won each of their last nine games against AL Central opponents following a home win.
• The White Sox have failed to cover the run line each of their last 13 Saturday night games against teams that held a winning record.
• The Brewers have covered the run line in seven of their last eight games against American League opponents that held a losing record.
• The White Sox have trailed after 5 innings in seven of their last eight road games against opponents that held a winning record.
• The Brewers have led after 3 innings in each of their last four games as home favorites against AL Central opponents.

Why the Chicago White Sox will win

• The White Sox have won four of their last five games as road underdogs against National League opponents following a loss.
• The Brewers have lost four of their last five games.
• The White Sox have covered the run line in each of their last 10 games against National League opponents following a loss.
• The Brewers have failed to cover the run line in each of their last eight Saturday home games against American League opponents.
• The Brewers have trailed after 5 innings in each of their last four games against opponents that held a losing record.
• The White Sox have won the first inning in four of their last five games against the Brewers.
• The White Sox have led after 3 innings in five of their last six night games against the Brewers.

Total Runs Facts

• Six of the Brewers’ last seven games have gone UNDER the total runs line.
• Four of the White Sox’s last five games as underdogs against the Brewers have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 11 of the Brewers’ last 12 night games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight road games against NL Central opponents.

Milwaukee Brewers Player Prop Facts

• Sal Frelick has hit a home run in each of his last two appearances against AL opponents.
• Sal Frelick has recorded at least one hit in each of his last 13 appearances with the Brewers as home favorites against AL opponents.
• Andrew Vaughn has recorded a Double in four of his last five appearances in night games against teams that held a losing record.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit at least one home run in four of his last five road appearances against NL Central opponents that held a winning record.
• Andrew Benintendi has recorded at least one hit in each of his last 12 appearances against NL Central opponents that held a winning record.

Brewers vs White Sox Prediction 

Milwaukee was able to explode offensively in game one to start the season with a bang and they will look for two in a row here. The Brewers will turn to Chad Patrick, who was very strong for them last season. The White Sox used a lot of their bullpen in game one and they will hope Burke can give them some innings, but his WHIP in 2025 was almost at 1.50. I don’t trust Burke on the mound against this lineup, so take Milwaukee to win by at least two runs here.