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Pirates vs Orioles Prediction 4/5/26 MLB Picks Today

Baltimore Orioles (3-5) vs. Pittsburgh Pirates (5-3)
April 5, 2026 1:35 pm EDT
The Line: Pittsburgh Pirates -131 / Baltimore Orioles 109; Over/Under: 8.5
(Get latest betting odds)

In this article we will formulate a Pirates vs Orioles prediction for this MLB game on Sunday, April 5th at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 5-3 this season after they won the first two games in this series by scores of 5-4 and 3-2. In the game two win, Pittsburgh trailed 2-0 in the fourth inning, but they scored once in the fourth, once in the eighth, and once in the ninth for the comeback win. The Pirates recorded eight hits in the game and they were led by Yorke, Horwitz, and Mangum, who all had one RBI. Mlodzinski allowed five hits and two earned runs over 4.2 innings in the no decision, while Santana picked up the win in relief. 

This season, Pittsburgh has a 3.50 ERA with a 1.39 WHIP and a .215 opponent batting average, while they have scored 37 runs with a .232 batting average and a .326 on base percentage. Oneil Cruz has led the Pirates with three home runs and seven RBIs, while Ryan O’Hearn has added two home runs and seven RBIs. The projected starting pitcher for Pittsburgh is Braxton Ashcraft, who is 0-1 with a 3.00 ERA and a 1.33 WHIP over 6.0 innings pitched this season. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 3-5 this year after they dropped game two by a score of 3-2 on Saturday afternoon. Baltimore jumped out to a 2-0 lead in the fourth inning, but their offense never scored again and the bullpen blew the game for the loss. The Orioles recorded six hits and they committed one error in the game, while they were led by Beavers and Taveras, who both had one RBI. Baz allowed three hits and zero earned runs over 5.2 innings in the no decision, while Nunez blew the save and Helsley was charged with the loss. 

This season, Baltimore has a 4.22 ERA with a 1.44 WHIP and a .247 opponent batting average, while they have scored 32 runs with a .249 batting average and a .337 on base percentage. Gunnar Henderson has led the Orioles with two home runs and six RBIs, while Tyler O’Neill has added one home run and three RBIs. The projected starting pitcher for Baltimore is Chris Bassitt, who is 0-1 with an 8.31 ERA and a 2.31 WHIP over 4.1 innings pitched this year. 

Why the Pittsburgh Pirates will win

  • The Pirates have won each of their last 11 day games at PNC Park following a win.
  • The Orioles have lost each of their last seven road games against teams that held a winning record.
  • The Pirates have covered the run line in each of their last nine day games at PNC Park following a win.
  • The Orioles have failed to cover the run line in each of their last five games against the Pirates following a loss.
  • The Orioles have trailed after 5 innings in five of their last six games as road underdogs against NL Central opponents.
  • The Orioles have trailed after 3 innings in each of their last six games as road underdogs against NL Central opponents.
  • The Orioles have lost the first inning in each of their last four games as road underdogs.

Why the Baltimore Orioles will win

  • The underdogs have won each of the Orioles’ last four games at PNC Park.
  • The Pirates have lost five of their last six games as home favorites against American League opponents following a win.
  • The underdogs have covered the run line in each of the last seven games between the Orioles and Pirates.
  • The Pirates have failed to cover the run line in 24 of their last 28 games as home favorites against American League opponents following a win.
  • The Orioles have led after 5 innings in four of their last five road games against National League opponents that held a winning record.

Total Runs Facts

  • Seven of the Orioles’ last eight games against National League opponents have gone UNDER the total runs line.
  • Thirteen of the Pirates’ last 15 games as favorites against AL East opponents have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Orioles’ last six day games.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Pirates’ last eight games as home favorites against AL East opponents.

Pittsburgh Pirates Player Prop Facts

  • Jared Triolo has hit a home run in three of the Pirates’ last four games as home favorites.
  • Bryan Reynolds has recorded at least one hit in each of the Pirates’ last seven games against opponents that held a losing record.
  • Brandon Lowe ranks T3rd in the league in Home Runs (3) this season.

Baltimore Orioles Player Prop Facts

  • Tyler O’Neill has hit a home run in four of his last seven appearances against NL opponents.
  • Chris Bassitt has recorded five or more strikeouts in each of his six previous appearances against the Pirates.
  • Adley Rutschman has recorded at least one hit in each of his last 10 road appearances against NL opponents.
  • Chris Bassitt has recorded a win in four of his last five appearances against the Pirates.

Matchup/League Facts

  • The Pirates rank T29th in the league for steals this season (1).
  • The Pirates rank T3rd in the league for home runs this season (10).
  • The Orioles rank T5th in the league for doubles this season (13).
  • The Orioles rank 7th in the league for on-base percentage this season (.336).

Pirates vs Orioles Prediction 

Baltimore had a great chance to get the win on Saturday to tie the series at one, but they couldn’t hold the lead in the later innings. The Orioles have allowed at least five runs in three of their last five games and they are starting Bassitt, who was terrible in his first start. Pittsburgh has won four in a row and they have allowed three runs or fewer in four of their last five. The Pirates are starting Ashcraft, who pitched well in his first start. Take the Pirates to get the win and sweep here. 

David Racey's Free Pick: Pirates ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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