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Orioles vs Giants Prediction 4/11/26 MLB Picks Today

San Francisco Giants (6-8) vs. Baltimore Orioles (6-7)
April 11, 2026 7:15 pm EDT
The Line: Baltimore Orioles 100 / San Francisco Giants -120; Over/Under: 7.5
(Get latest betting odds)

In this article we will formulate an Orioles vs Giants prediction for this MLB game on Saturday, April 11th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 6-7 this season after they lost game one in this series by a score of 6-3 on Friday night. Baltimore cut the deficit to 3-1 in the fourth inning, but they allowed the next three runs to seal the loss. The Orioles recorded eight hits in the game and they were led by Henderson, who went 1-4 with one home run and two RBIs. Baz allowed nine hits and three earned runs over 5.0 innings for the loss, while Raquet allowed three earned runs in relief. Prior to this series, Baltimore swept the White Sox in three games, but lost all three against the Pirates before that. 

This season, Baltimore has a 4.09 ERA with a 1.40 WHIP and a .243 opponent batting average, while they have scored 48 runs with a .241 batting average and a .328 on base percentage. Gunnar Henderson has led the Orioles with five home runs and 11 RBIs, while Taylor Ward has added zero home runs and eight RBIs. The projected starting pitcher for Baltimore is Chris Bassitt, who is 0-2 with a 14.21 ERA and a 2.84 WHIP over 6.1 innings pitched this season. 

San Francisco Giants Betting Preview

The San Francisco Giants are 6-8 this year after they won game one by a score of 6-3 on Friday night. San Francisco led 3-0 in the fourth inning and they added three runs in the seventh to get the win. The Giants recorded 12 hits and they committed one error, while they were led by Lee and Adames, who both had two RBIs in the game. Roupp allowed five hits and one earned run over 6.0 innings for the win, while Tidwell added two earned runs in relief. Prior to this series, San Francisco won two out of three against the Phillies, but lost three out of four against the Mets before that. 

This season, San Francisco has a 3.96 ERA with a 1.34 WHIP and a .241 opponent batting average, while they have scored 47 runs with a .240 batting average and a .289 on base percentage. Matt Chapman has led the Giants with one home run and seven RBIs, while Rafael Devers has added two home runs and six RBIs. The projected starting pitcher for San Francisco is Logan Webb, who is 1-1 with a 5.00 ERA and a 1.39 WHIP over 18.0 innings pitched this year. 

Why the Baltimore Orioles will win

  • The Giants have lost each of their last four games as road favorites against AL East opponents following a win.
  • The underdogs have won five of the Giants’ last six games.
  • The Giants have failed to cover the run line in 14 of their last 15 Saturday games as favorites.
  • The Orioles have covered the run line in six of their last seven games as home underdogs against National League opponents.
  • The Orioles have led after 3 innings in three of their last four home games against NL West opponents that held a losing record.

Why the San Francisco Giants will win

  • The Giants have won seven of their last eight road games against AL East opponents that held a losing record.
  • The Orioles have lost seven of their last eight night games against NL West opponents that held a losing record.
  • The Orioles have failed to cover the run line in seven of their last eight games against National League opponents.
  • The Giants have covered the run line in seven of their last eight road games against AL East opponents that held a losing record.
  • The Orioles have lost the first inning in four of their last five games as underdogs.
  • The Orioles have trailed after 3 innings in each of their last six games as underdogs.
  • The Giants have led after 5 innings in each of their last five night games against the Orioles.

Total Runs Facts

  • Each of the last eight games between the Giants and Orioles have gone OVER the total runs line.
  • Each of the Giants’ last six games as favorites against AL East opponents have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Orioles’ last nine games.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last four games against American League opponents.

Baltimore Orioles Player Prop Facts

  • Tyler O’Neill has hit a home run in each of his last four home appearances against NL West opponents.
  • Chris Bassitt has recorded four or more strikeouts in each of his last 13 home appearances against opponents that held a losing record.
  • Chris Bassitt has recorded a win in each of his last five home appearances against NL opponents that held a losing record.
  • Pete Alonso has recorded at least one hit in each of his last 11 home appearances after playing the previous day.

San Francisco Giants Player Prop Facts

  • Willy Adames has hit at least one home run in each of his last two appearances with his team as a road favorite against AL East opponents.
  • Logan Webb has recorded a win in each of his last four road appearances against opponents that held a losing record.
  • Luis Arraez has recorded at least one hit in each of his last 25 appearances with his team as a favorite against AL opponents.

Orioles vs Giants Prediction 

San Francisco comes into this matchup on a three game winning streak and they have scored 17 runs in those three wins. The Giants are 3-1 on the road this year, while the Orioles are 3-4 at home. Baltimore has won three of their last four games, but all three wins came against the lowly White Sox. Neither pitcher has started the season playing very well and with Bassitt being very shaky, I like the over here. 

David Racey's Free Pick: Over 7.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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