Padres vs Cubs Prediction 4/28/26 MLB Picks Today

The Chicago Cubs and San Diego Padres meet Tuesday in MLB action at Petco Park. Here’s a Padres vs. Cubs Prediction. This article will include a Padres vs. Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 17-12 on the year and play the Diamondbacks and Reds next. The Chicago Cubs are batting .262 on the season and have a .352 OBP, and a .426 slugging percentage. The Chicago Cubs pitching staff has a 4.05 ERA and a 1.22 WHIP. Nico Hoerner leads the Chicago Cubs with 35 hits and 24 RBI, while Alex Bregman and Pete Crow-Armstrong have combined for 55 hits and 17 RBI.

Edward Cabrera gets the ball for the Chicago Cubs, and he is 2-0 with a 2.73 ERA and 22 strikeouts this season. Cabrera is 1-0 with a 0.54 ERA and 17 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 19-9 on the year and play the Giants and White Sox next. The San Diego Padres are batting. 240 on the season, have a .315 OBP, and have a .390 slugging percentage. The San Diego Padres pitching staff has a 4.07 ERA and a 1.29 WHIP. Xander Bogaerts leads the San Diego Padres with 29 hits and 16 RBI, while Ramon Laureano and Fernando Tatis Jr. have combined for 53 hits and 30 RBI.

Walker Buehler gets the ball for the San Diego Padres, and he is 1-2 with a 5.75 ERA and 20 strikeouts this season. Buehler is 1-3 with a 4.54 ERA and 31 strikeouts in his career against the Chicago Cubs.

Why the San Diego Padres will win

• The Padres have won each of their last nine home games.
• The Cubs have lost nine of their last 10 road games against National League opponents that held a winning record.
• The Padres have covered the run line in each of their last six home games against National League opponents.
• The Cubs have failed to cover the run line in nine of their last 10 games against teams that held a winning record.
• The Cubs have trailed after 5 innings in each of their last nine road games against National League opponents that held a winning record.
• The Padres have won the first inning in three of their last four home games against NL Central opponents.

Why the Chicago Cubs will win

• The Padres have lost 10 of their last 11 games against the Cubs following a win.
• The Cubs have won eight of their last nine games against the Padres following a loss.
• The favorites have covered the run line in each of the last four games between the Cubs and Padres.
• The Padres have failed to cover the run line in five of their last six games following a win.
• The Padres have trailed after 5 innings in five of their last six games as underdogs against National League opponents.
• The Padres have trailed after 3 innings in four of their last five games.

Total Runs Facts

• Seven of the Cubs’ last eight night games against National League opponents have gone OVER the total runs line.
• Each of the Padres’ last four games as underdogs has gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last nine games as underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cubs’ last eight games at Petco Park.

San Diego Padres Player Prop Facts

• Nick Castellanos has recorded at least one hit in each of his last 13 appearances against the Cubs.
• Luis Campusano has hit a home run in each of his last three appearances against NL opponents.
• Fernando Tatis Jr. ranks T9th in the league in Steals (7) this season.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit a home run in three of the Cubs’ last four night games.
• Edward Cabrera has recorded six or more strikeouts in each of his four previous appearances with his team as a favorite against NL West opponents.
• Ian Happ has recorded at least one hit in each of his last 11 appearances with the Cubs as road favorites against NL West opponents.
• Nico Hoerner ranks T6th in the league in Hits (35) this season.

Matchup/League Facts

• The Padres rank 2nd in the league for home runs allowed this season (22).
• The Padres rank T3rd in the league for doubles this season (54).
• The Cubs rank 2nd in the league for on-base percentage this season (.352).
• The Cubs rank T3rd in the league for runs scored this season (156).

Padres vs Cubs Prediction

The Cubs are probably the rightful favorite, as Buehler hasn’t looked good through 20.1 innings. Cabrera has always been a talented arm and he’s putting together possibly his best season yet. Through 29.2 innings, Cabrera has a 2.73 ERA and 1.18 WHIP with 24 strikeouts. However, I keep saying that this Padres team has some magic to them and they keep finding ways to win. If you’re going to give me plus money with a team that’s currently pushing the Dodgers and Braves for the best record in baseball, I’ll take it, especially at home. I like Cabrera and the Cubs have an edge on the bump. Still, give me the home dog on Tuesday.