Wake Forest Demon Deacons (2-1) vs. Louisville Cardinals (2-1)
September 26, 2026 12:00 pm EDT
The Line: Louisville Cardinals -13.5 / Wake Forest Demon Deacons 13.5; Over/Under: 57.5
(Get latest betting odds)
The Wake Forest Demon Deacons and Louisville Cardinals meet Saturday in week 4 college football action at L&N Federal Credit Union Stadium. Here’s a Louisville vs. Wake Forest Prediction. This article will include a Louisville vs. Wake Forest Pick.
Wake Forest Demon Deacons Betting Preview
The Wake Forest Demon Deacons beat Purdue, lost to Miami, and they play Stanford next. Wake Forest has won 6 of its last 8 games. Gio Lopez is completing 62.9 percent of his passes for 887 yards, 7 touchdowns, and 1 interception. Carlos Hernandez and Antonio Meeks have combined for 456 receiving yards and 3 touchdowns, while Jack Foley has 6 receptions.
The Wake Forest Demon Deacons ground game is averaging 137 yards per contest, and Ty Clark III leads the way with 144 yards and 1 touchdown. Defensively, Wake Forest is allowing 28.3 points and 379.3 yards per game. Vincent Firenze leads the Wake Forest Demon Deacons with 26 tackles, Langston Hardy has 2 sacks, and Davaughn Patterson has 3 pass deflections.
Louisville Cardinals Betting Preview
The Louisville Cardinals beat Villanova and SMU, and they play NC State next. Louisville has won 4 of its last 5 games. Lincoln Kienholz is completing 65.8 percent of his passes for 816 yards, 6 touchdowns, and 0 interceptions. Tre Richardson and Lawayne McCoy have combined for 469 receiving yards and 4 touchdowns, while Jaleel Skinner has 8 receptions.
The Louisville Cardinals’ ground game is averaging 229 yards per contest, and Keyjuan Brown leads the way with 231 yards and 2 touchdowns. Defensively, Louisville is allowing 28.3 points and 406.7 yards per game. Kaleb Beasley leads the Louisville Cardinals with 22 tackles, Clev Lubin has 1.5 sacks, and Stanquen Clark has 1 interception.
Why the Louisville Cardinals will win
- Louisville has won each of its last 12 September games against non-AP-ranked teams.
- Wake Forest has lost nine of its last 10 games against AP-ranked teams.
- Louisville has covered the spread in each of its last four games against Wake Forest.
- Wake Forest has failed to cover the spread in six of its last eight road games in September.
- Louisville has won the first half in 13 of its last 14 September home games against non-AP-ranked teams.
- Louisville has won the first quarter in each of its last five games.
Why the Wake Forest Demon Deacons will win
- Wake Forest has won each of its last four September games as a road underdog.
- Louisville has lost three of its last four games against conference opponents.
- The team ranked 16th in the AP Poll has failed to cover the spread in each of its last five games.
- The underdog has covered the spread in each of Wake Forest’s last four games.
- Louisville has lost the first half in each of its last five games against conference opponents.
- Wake Forest has won the first quarter in four of its last six September games as a road underdog.
Total Points Facts
- Each of the last six games between Wake Forest and Louisville have gone OVER the total points line.
- Thirteen of Wake Forest’s last 15 road games against AP-ranked teams have gone UNDER the total points line.
Louisville Cardinals Player Prop Facts
- Heading into Week 4, Kaleb Beasley ranks T8th amongst FBS players for interceptions (2) this season.
Wake Forest Demon Deacons Player Prop Facts
- Heading into Week 4, Gio Lopez ranks T8th in the league for TD: INT ratio (7.00) this season.
Matchup/League Facts
- Louisville ranks 1st among FBS teams for H2 points per game this season (29.0).
- Louisville ranks T1st among FBS teams for red zone percentage this season (100.0).
- Wake Forest ranks T127th among FBS teams for 1st downs against this season (72).
- Wake Forest ranks 25th among FBS teams for passing yards per game this season (297.7).
Louisville vs Wake Forest Prediction
This could be a letdown spot for Louisville after a big game against SMU, but Wake Forest hasn’t played a lick of defense up to this point, and that’s concerning. Purdue, of all teams, lit up the Demon Deacons for 36 points and took them to double overtime. These playmakers for Louisville should have a field day, and I’m not sure Wake Forest has the horses to counter. Louisville is also 3-0 ATS on the season. I like the Cardinals by two touchdowns.
