Cardinals vs Brewers Prediction 9/25/26 MLB Picks Today

In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB matchup on Friday, September 25^th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 100-59 record this season and are sitting in the 1st place of the NL Central. They have a 52-26 home record and are coming off a 5-1 road win against the Phillies.

The Milwaukee Brewers have a .258 batting average this season, .340 OBP and .402 Slugging percentage. Milwaukee’s pitching staff has a 3.52 ERA and 1.19 WHIP. Jackson Chourio is the team’s best hitter with a .285 batting average. Brice Turang leads the team in RBI with 94, while Jake Bauers adds a team-high 26 home runs.

Robert Gasser (L) is the projected starting pitcher for the Brewers, and he has a 5-5 record, 4.01 ERA and 1.24 WHIP.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 77-82 record this season and are sitting in the 4th place of the NL Central. They have a 39-39 away record and are coming off a 1-2 road loss against the Pirates.

The St. Louis Cardinals have a .241 batting average this season, .314 OBP and .379 Slugging percentage. St. Louis’s pitching staff has a 4.24 ERA and 1.35 WHIP. Alec Burleson is the team’s best hitter with a .279 batting average, leading the team in RBI with 113, while Jordan Walker adds a team-high 28 home runs.

Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 7-9 record, 3.84 ERA and 1.25 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 25, 2026

• Probable Starting Pitcher: Robert Gasser      Record this season: 5-5      ERA: 4.01
• Home Record: 1-2
• Last 5 against Cardinals: 2-1

Why the Milwaukee Brewers will win

• The Brewers have won each of their last eight night games after playing the previous day.
• The Cardinals have lost eight of their last nine night games at American Family Field following a loss.
• The Brewers have covered the run line in each of their last six home games following a road win.
• The Cardinals have failed to cover the run line in six of their last seven night games against NL opponents.
• The Brewers have led after 3 innings in seven of their last eight games as favorites against NL opponents.
• The Brewers have won the first inning in six of their last seven home games against opponents that held a losing record.
• The Brewers have led after 5 innings in seven of their last eight home games against NL opponents that held a losing record.

• Probable Starting Pitcher: Michael McGreevy      Record this season: 7-9      ERA: 3.84
• Road Record: 4-5
• Last 5 against Brewers: 1-1

Why the St. Louis Cardinals will win

• The Brewers have lost three of their last four games as favorites against NL Central opponents following a road win.
• The Cardinals have won three of their last four games as underdogs against NL Central opponents following a road loss.
• The Brewers have failed to cover the run line in 12 of their last 13 games as favorites against the Cardinals following a win.
• The Cardinals have covered the run line in 11 of their last 12 games as underdogs after playing the previous day.
• The Cardinals have led after 5 innings in five of their last six night games against NL Central opponents.
• The Cardinals have led after 3 innings in four of their last five night games against opponents that held a winning record.

Total Runs Facts

• Each of the Cardinals’ last four games have gone UNDER the total runs line.
• Each of the last four games between the Cardinals and Brewers at American Family Field have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of the Brewers’ last 10 night games at American Family Field.
• There has been at least one run scored in the first inning in seven of Michael McGreevy’s last eight road appearances as a starter.

Milwaukee Brewers Player Prop Facts

• William Contreras has hit a home run in each of his last three home appearances.
• Joey Ortiz has recorded at least one hit in each of his last 10 appearances against NL opponents.
• Jake Bauers ranks 2nd amongst qualified players for On Base Percentage (.393) this season.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in three of the Cardinals’ last five games against NL Central opponents that held a winning record.
• Michael McGreevy has recorded a win in each of his last three appearances against opponents that held a winning record.
• Michael McGreevy has recorded four or more strikeouts in each of his last six road appearances.
• JJ Wetherholt has recorded two or more hits in each of his last four road appearances after playing the previous day.
• Alec Burleson ranks T9th in the league in Hits (167) this season.

Matchup/League Facts

• The Brewers rank 1st in the league for hits this season (1392).
• The Brewers rank 1st in the league for on-base percentage this season (.340).
• The Cardinals rank 27th in the league for slugging percentage this season (.379).
• The Cardinals rank 4th in the league for home runs allowed this season (156).

Cardinals vs Brewers Prediction

The Brewers are 8-1 in their last 9 meetings against the Cardinals and have won their last three meetings in Milwaukee.

In this Cardinals vs Brewers Prediction, the Brewers are coming as -175 home favorites. Both teams have nothing to play for, so I will target the total in this game. Both pitchers have been in good form and both bullpens in excellent shape. Both teams have been playing lower-scoring games lately, as they are 8-1 to the under in their last 9 games combined, so I expect another low-scoring affair today. Take the under 8 runs.