Nebraska vs Michigan State Prediction Football Picks Today 9/26/26
Nebraska Cornhuskers (3-0) vs. Michigan State Spartans (2-1)
September 26, 2026 5:00 pm EDT
The Line: Michigan State Spartans 185 / Nebraska Cornhuskers -225; Over/Under: 48.5
(Get latest betting odds)
In this article, we will formulate a Nebraska vs Michigan State Prediction for this College Football Week 4 matchup on Saturday, September 26th. Let’s take a look at the prediction for this College Football matchup.
Michigan State Spartans Preview
Michigan State has a 2-1 record and are coming off a 10-27 road loss against Notre Dame. They will face Wisconsin and Illinois next. Offensively, Michigan State averages 25 points per game, ranking 101st in the nation, while defensively, they allow 18 points per game, which is 47th. Michigan State averages 345.3 total yards per game (194.7 passing and 150.7 rushing), while allowing 295.7 total yards per game (113 rushing and 182.7 passing).
Alessio Milivojevic leads Michigan State with 540 passing yards with 66.2% completed passes and 3 touchdowns. Camryn Edwards leads the team in rushing yards with 288, while Rodney Bullard has a team-high 12 receptions for 182 receiving yards. Defensively, Devin Vaught has a team-high 18 total tackles (10 of them solo), while Eli Coenen leads the team with 3 sacks.
Nebraska Cornhuskers Preview
Nebraska has a 3-0 record and are coming off a 34-7 home win against North Dakota. They will face Maryland and Indiana next. Offensively, Nebraska averages 46.3 points per game, while defensively, they allow 11.7 points per game. Nebraska averages 461 total yards per game (230.7 passing and 230.3 rushing), while allowing 300.7 total yards per game (146.7 rushing and 154 passing).
Anthony Colandrea leads Nebraska with 692 passing yards with 8 touchdowns. Jamal Rule leads the team in rushing yards with 329, while Jacory Barney Jr. has a team-high 15 receptions for 210 receiving yards. Defensively, DeShon Singleton has a team-high 16 total tackles, while Riley Van Poppel leads the team with 2 sacks.
Nebraska Cornhuskers @ Michigan State Spartans Betting Trends: Week 4
Why the Michigan State Spartans will win
- The home team has won each of the last six games between Nebraska and Michigan State.
- Nebraska has lost each of its last four games in Michigan.
- Nebraska has failed to cover the spread in each of its last seven games against teams from Michigan.
- Michigan State has covered the spread in seven of its last eight games as an underdog.
- Michigan State has won the first quarter in each of its last six September games against non-AP-ranked teams.
- Michigan State has won the first half in six of its last seven September games against non-AP-ranked teams.
Why the Nebraska Cornhuskers will win
- Nebraska has won each of its last 10 September games against non-AP-ranked teams.
- Michigan State has lost each of its last 11 games as an underdog.
- Michigan State has failed to cover the spread in eight of its last nine games against non-AP-ranked teams at Spartan Stadium.
- Nebraska has covered the spread in seven of its last eight September games against non-AP-ranked teams.
- Michigan State has lost the first half in each of its last 11 games as an underdog.
- Nebraska has won the first quarter in four of its last five road games against conference opponents.
Total Points Facts
- Each of Michigan State’s last four games as an underdog have gone UNDER the total points line.
- Each of Nebraska’s last four games against teams from Michigan have gone OVER the total points line.
Michigan State Spartans Player Prop Facts
- Heading into Week 4, Eli Coenen ranks T9th amongst FBS players for sacks (3.0) this season.
Nebraska Cornhuskers Player Prop Facts
- Heading into Week 4, Jamal Rule ranks T6th amongst FBS players for touchdowns (6) this season.
Matchup/League Facts
- Michigan State ranks T9th among FBS teams for sacks this season (9.0).
- Michigan State ranks T16th among FBS teams for 4th down conversion percentage this season (85.7).
- Nebraska has recorded the equal-most home wins by a margin of 10+ points of any FBS team this season (3).
- Nebraska has recorded the equal-most home wins by a margin of 15+ points of any FBS team this season (3).
Nebraska vs Michigan State Prediction
In this Nebraska vs Michigan State Prediction, Nebraska is coming as -5.5 road favorites. Nebraska has been undefeated this season and have superior numbers both offensively and defensively, with a +34.6 point differential. They score 46.3 ppg and have allowed just 14 total points in their last two games combined, while Michigan State has allowed 47 points in two of its three games this season. On top of that, Nebraska is 3-1 against the spread in its last three visits in Michigan State, so I will lay the -5.5 on the road with the Cornhuskers in this one.