USC vs Penn State Prediction Football Picks Today 10/10/26

In this article, we will formulate a USC vs Penn State Prediction for this College Football Week 6 matchup on Saturday, October 10^th. Let’s take a look at the prediction for this College Football matchup.

Penn State Nittany Lions Preview

Penn State has a 3-2 record and a 0-2 record in the Big Ten. They are coming off a 34-13 home win against Northwestern and will face Michigan and Purdue next. Offensively, Penn State averages 32 points per game, ranking 63rd in the nation, while defensively, they allow 16 points per game, which is 25th. Penn State averages 400 total yards per game (243.6 passing and 156.4 rushing), while allowing 292.8 total yards per game (173.2 rushing and 119.6 passing).

Rocco Becht leads Penn State with 1,108 passing yards with 61.9% completed passes and 10 touchdowns. James Peoples leads the team in rushing yards with 212, while Koby Howard has a team-high 12 receptions for 344 receiving yards. Defensively, Tony Rojas has a team-high 34 total tackles (21 of them solo), also adding a team-high 3 sacks.

USC Trojans Preview

USC has a 5-1 record and a 2-1 record in the Big Ten. They are coming off a 25-21 home win against Washington and will face Wisconsin and Ohio State next. Offensively, USC averages 37.3 points per game, ranking 29th in the nation, while defensively, they allow 25.5 points per game, which is 89th. USC averages 467.8 total yards per game (311.7 passing and 156.2 rushing), while allowing 348.8 total yards per game (118.2 rushing and 230.7 passing).

Jayden Maiava leads USC with 1,744 passing yards with 68.6% completed passes and 15 touchdowns. King Miller leads the team in rushing yards with 493, while Kayden Dixon-Wyatt has a team-high 25 receptions for 372 receiving yards. Defensively, Christian Pierce has a team-high 35 total tackles (23 of them solo), while Kennedy Urlacher leads the team with 2 sacks.

USC Trojans @ Penn State Nittany Lions Betting Trends: Week 6

Why the Penn State Nittany Lions will win

• USC has lost each of its last 10 October games as an underdog.
• The favorite has won 13 of USC’s last 14 games.
• USC has failed to cover the spread in each of its last six games against conference opponents.
• Penn State has covered the spread in four of its last five home games.
• Penn State has won the first quarter in each of its last four home games.
• Penn State has won the first half in each of its last 10 October games as a home favorite.

Why the USC Trojans will win

• USC has won 16 of its last 17 games against non-AP-ranked teams.
• Penn State has lost each of its last six October games against AP-ranked teams.
• Penn State has failed to cover the spread in six of its last seven October games as a favorite.
• The underdog has covered the spread in six of USC’s last eight games.
• USC has won the first quarter in three of its last four October games as an underdog.
• USC has won the first half in four of its last five games against non-AP-ranked teams.

Total Points Facts

• Six of Penn State’s last seven games against AP-ranked teams at West Shore Home Field at Beaver Stadium have gone UNDER the total points line.
• Five of USC’s last six games as an underdog have gone OVER the total points line.

Penn State Nittany Lions Player Prop Facts

• Heading into Week 6, Koby Howard ranks 1st amongst qualified players for Yards Per Reception (28.7) this season.

USC Trojans Player Prop Facts

• Heading into Week 6, Jayden Maiava ranks 2nd amongst FBS players for passing yards (1744) this season.

Matchup/League Facts

• Penn State has recorded the equal-most home wins by a margin of 40+ points of any FBS team this season (2).
• Penn State ranks 3rd among FBS teams for passing yards allowed per game this season (119.6).
• USC ranks 1st among FBS teams for 1st downs this season (152).
• USC ranks 10th among FBS teams for 3rd down conversion percentage this season (52.1).

USC vs Penn State Prediction

In this USC vs Penn State prediction, Penn State is coming as -1.5 home favorites. USC has lost only once this season but it has failed to cover the spread in each of its last four games and its defensive numbers are inflated because of a 39-0 win against Fresno in Week 2. They have allowed 30+ points in three of their last four games after that and will face a Penn State squad that looks to bounce back after back-to-back losses and have the 25^th-best defense in the entire country and a +16 point differential this season. Take Penn State to win this outright.