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Clemson vs Notre Dame Prediction 2/26/25 College Basketball Picks Today

Notre Dame (12-15) vs. Clemson (22-5)
February 26, 2025 7:00 pm EDT
The Line: Clemson -14.5; Over/Under: 136.5
(Get latest betting odds)

The Notre Dame Fighting Irish and the Clemson Tigers meet Wednesday in college basketball action from the Littlejohn Coliseum. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Clemson vs Notre Dame Prediction.

Matchup History

These two teams have not met this season, but on March 2nd, 2024, Notre Dame picked up a 69-62 win over Clemson to make it four wins in the last five head-to-head meetings for Notre Dame in this matchup.


Notre Dame Recap

The Notre Dame Fighting Irish come into this game looking to add on to their 76-72 win over Pitt last time out to improve to 12-15 on the year. After this game, Notre Dame will head on the road for a game against Wake Forest.

Irish Looking To Build Some Momentum

Markus Burton has logged 20.3 PPG with 3.4 RPG and 3 APG in 20 games played so far this season, while Tae Davis has 15.8 PPG with 5.4 RPG. Braeden Shrewsberry has 14 PPG with 3 RPG to round out the group of double-digit scorers for Notre Dame so far this season. Matt Allocco has 9 PPG with 4.4 RPG and 3 APG and Kebba Njie also has 6.3 PPG with a team-high 6.2 RPG to lead Notre Dame in rebounding as well this season. As a team, Notre Dame is averaging 73.3 PPG on 45.7% shooting from the field, 36.2% from behind the arc, and 74.3% from the charity stripe this season.

Why the Notre Dame Fighting Irish will win

  • The road team has won four of Notre Dame’s last five games.

Clemson Recap

The Clemson Tigers come into this game looking to add on to their 79-69 win over SMU last time out to improve to 22-5 on the year. After this game, Clemson will head on the road for a game against Virginia.

Tigers Win Four In A Row

Chase Hunter leads Clemson in scoring with a team-high 17 PPG with 3 RPG and 2.5 APG while Viktor Lakhin has 11.2 PPG with 6.1 RPG. Ian Schieffelin has 12.4 PPG with a team-high 9.4 RPG and 3.2 APG to lead the Tigers in rebounding. Jaeden Zackary also has 10.9 PPG with a team-high 3.4 APG to lead Clemson in assists, while also capping off the trio of double-digit scorers for Clemson so far this season. Chauncey Wiggins also has 9.2 PPG with 3 RPG as well this season. As a team, Clemson is averaging 77.5 PPG on 46.9% shooting from the field, 38.8% from three, and 76.9% from the foul line this season.

Why the Clemson Tigers will win

  • Notre Dame has lost each of its last eight games against AP-ranked opponents.
  • Clemson has won 23 of its last 24 Wednesday games at Littlejohn Coliseum.

Total Points Facts

  • Each of Clemson’s last six night games against Conference opponents at Littlejohn Coliseum has produced a total of 148+ points.
  • Ten of Notre Dame’s last 11 road night games against Conference opponents have produced a total of 135 or fewer points.

Notre Dame vs. Clemson Prediction

I’m on Clemson in this game. I’m just out on Notre Dame as a whole, as I think the Irish are a sunken ship that’s just playing out the string at this point. Clemson hasn’t had a lot go wrong in a lot of their recent games, and I think that they’re the better team by a fair margin in this game. This to me feels like a game where Clemson steadily pulls away over the course of the second half for a win and cover in this one, so give me Clemson laying the points here.

Chris Ruffolo's Free Pick: Clemson -14.5

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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