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DePaul vs Creighton Prediction 1/21/25 College Basketball Picks Today

Creighton (12-6) vs. DePaul (10-9)
January 21, 2025 9:00 pm EDT
The Line: DePaul +6; Over/Under: 146.5
(Get latest betting odds)

In this article, we will formulate a DePaul vs Creighton Prediction for this college basketball game on Tuesday, January 21st, at the Wintrus Arena. Let’s take a DePaul Blue Demons vs Creighton Bluejays pick. 

Creighton is Heating Up

Creighton went through a little lull, but they have figured it out again and they have all kinds of confidence right now. Two games ago against Providence, Creighton was able to secure the 84-64, and in the last game against UConn, they were able to secure the 68-63 victory. At halftime, they were up 35-28 and even though they didn’t play as well in the second half they were still able to pick up the win. Jamiya Neal put up 24 points, four rebounds, and one assist. There were three different players that put up at least 12 points. 



Creighton comes into this game with a 12-6 record and they have gone 9-7-2 against the spread. Creighton is averaging 75.4 points while their defense is giving up 70.1 points per game. The offense is ranked 172nd in the league while the defense is ranked 140th in the league. Ryan Kalkbrenner is averaging 17.7 points while shooting 65.4 percent from the field and 40.7 percent from behind the three-point line. 

What a Win for DePaul

DePaul in the last game faced off against Georgetown and they were able to secure a 73-68 victory. At halftime, they were up 39-28 and even though they weren’t as good in the second half they were still able to secure the win. CJ Gunn had a strong game putting up 17 points and five rebounds. Two games ago against Marquette, the offense scored 83 points but the defense gave up 85 points and that led to the defeat. 

DePaul sits with a 10-9 record overall and they have gone 8-10-1 against the spread. DePaul on the season is averaging 77.1 points while their defense is giving up 73.8 points per game. The offense is ranked 121st in the league while the defense is ranked 252nd. Guard Jacob Meyer has been the top player for DePaul averaging 13.6 points while shooting 42.5 percent from the field and 38.5 percent from behind the three-point line. 

Why Creighton Will Beat DePaul

  • DePaul has lost each of its last 19 games against the Big East Conference at Wintrust Arena.
  • Creighton has won each of its last 14 night games against DePaul.
  • DePaul has lost the first half in 13 of its last 15 games against the Big East Conference at Wintrust Arena.

Total Points Facts

  • Ten of Creighton’s last 11 night games against Conference opponents have produced a total of 147+ points.
  • Eight of DePaul’s last 10 games have produced a total of 148+ points.

DePaul vs Creighton Prediction

Creighton is playing with so much confidence right now I am not about to bet against them. DePaul’s defense has been a major problem and they are going to really struggle again here. They are giving up 73.8 points per game and they are going ot give up at least that here. Creighton’s offense is going to run up the score and they will end up cruising here. Back Creighton against the spread. 

Shane Mickle's Free Pick: Creighton -6

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Shane Mickle

Sports is about all Shane knows in this life! He has a passion for sports and writing, which makes working for Sportschatplace a perfect job for him! If you find him cheering for a team it's usually a Minnesota team, or the Kansas Jayhawks!

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