DePaul vs UConn Prediction 12/21/25 College Basketball Picks Today

The UConn Huskies and the Depaul Blue Demons meet Sunday in college basketball action from the Wintrust Arena. We will look at this from a betting perspective and determine the best bets for this game. Here’s a UConn Huskies vs. Depaul Blue Demons prediction.

UConn Huskies Recap

The UConn Huskies come into this game looking to add on to their 79-60 win over Butler last time out to sit at 11-1 on the year. After this game, UConn will head on the road for a game against Xavier.

Huskies Win 7 In A Row

Tarris Reed Jr. has 15.5 PPG with 8.3 RPG while Alex Karaban’s put up 13.4 PPG with 5.8 RPG and 2.3 APG. Solo Ball has 14.6 PPG with 3.6 RPG and Silas Demary Jr. has 10.4 PPG with 4.7 RPG and a team-high 5.6 APG to lead the Huskies in assists and to cap off the group of double-digit scorers for UConn up to this point in the year. Eric Reibe has 9.7 PPG with 4.9 RPG and Braylon Mullins has 9.7 PPG with 3 RPG as well this season. As a team, UConn is averaging 80.1 PPG on 49.1% shooting from the field, 33.3% from three and 71.2% from the foul line this season.

Why the Connecticut Huskies will win

• DePaul has lost each of its last 21 games against AP-ranked opponents.
• Connecticut has won each of its last 11 December games as an AP-ranked team.

Depaul Blue Demons Recap

The Depaul Blue Demons come into this game looking to shake off a 79-66 loss at the hands of St. John’s last time out to sit at 8-4 this season. After this game, Depaul will head on the road for a game against Villanova.

Blue Demons Have Three-Game Win Streak Snapped

CJ Gunn leads the Blue Demons in scoring with 13.8 PPG along with 3.4 RPG while Layden Blocker has 12.2 PPG with 2.3 RPG and a team-high 3.7 APG to lead the Blue Demons in assists. NJ Benson has 11.2 PPG with a team-high 6.9 RPG to lead the Blue Demons in rebounding and to cap off the group of double-digit scorers for Depaul up to this point in the year. Kaleb Banks also has 8.1 PPG with 2.5 RPG and Kaleb Banks has 8.1 PPG with 2 RPG and 2.3 APG as well this season. As a team, Depaul is averaging 79 PPG on 45.6% shooting from the field, 34.1% from three and 70.4% from the foul line this season.

Why the DePaul Blue Demons will win

• DePaul has won each of its last four games at Wintrust Arena.

Total Points Facts

• Each of DePaul’s last nine games against Conference opponents have produced a total of 138+ points.
• Each of Connecticut’s last eight Sunday games against Conference opponents have produced a total of 142+ points.

UConn Huskies vs. Depaul Blue Demons Prediction

I’m on UConn here. I just don’t think that Depaul has what it takes to hang with UConn for a full 40 minutes, even at home, as I just think the Blue Demons are once again far overmatched when it comes to the rigors of Big East conference play. UConn has owned this matchup over the years and I don’t expect that to change this season either. Give me UConn in this one.