Louisville vs Kentucky Prediction 11/11/25 College Basketball Picks Today

The Kentucky Wildcats and the Louisville Cardinals meet Tuesday in college basketball action from the KFC Yum! Center. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Kentucky Wildcats vs. Louisville Cardinals prediction.

Kentucky Wildcats Recap

The Kentucky Wildcats come into this game looking to add on to their 107-59 win over Valparaiso last time out to sit at 2-0 on the year. After this game, Kentucky will head home for a game against Eastern Illinois.

Wildcats Looking To Stay Unbeaten

Collin Chandler leads Kentucky with 14.5 PPG along with 3.5 RPG and 4 APG and Otega Oweh has 14 PPG with 4 RPG this season. Malachi Moreno has 11.5 PPG with 9.5 RPG to lead the Wildcats on the glass while Denzel Aberdeen has 11 PPG with 4.5 RPG and 4 APG. Mouhamed Dioubate’s added 10.5 PPG with 6 RPG and 2 APG while Brandon Garrison and Jasper Johnson each have 10 PPG with Garrison logging 4.5 RPG and 2.5 APG and Jasper Johnson’s added a team-high 4.5 APG to lead the Wildcats in assists and to round out the group of double-digit scorers for Kentucky up to this point in the year. As a team, Kentucky’s averaging 92 PPG on 50.8% shooting from the field, 32.7% from three and 70.8% from the foul line this season.

Why the Kentucky Wildcats will win

• Louisville has lost each of its last nine games against AP-ranked opponents at KFC Yum! Center.
• Kentucky has won eight of its last nine games against non-Conference opponents.

Louisville Cardinals Recap

The Louisville Cardinals come into this game looking to improve on a 106-70 win over Jackson State last time out to sit at 2-0 this season. After this game, Louisville will head home for a game against Ohio.

Cardinals Looking For Revenge Vs. Kentucky

Khani Rooths leads the Cardinals in scoring and rebounding with 18 PPG and 8.5 RPG while Ryan Conwell has 15.5 PPG with 5.5 RPG and Mikel Brown Jr. has 14.5 PPG with 4 RPG and a team-high 7.5 APG to lead Louisville in assists. J’Vonne Hadley has 13 PPG while Isaac McKneely has 12.5 PPG and Sananda Fru has 10.5 PPG with 6.5 RPG to cap off the group of double-digit scorers for Louisville up to this point in the year. After this season, Louisville is averaging 105 PPG on 52.7% shooting from the field, 33.8% from three and 76.5% from the foul line this season.

Why the Louisville Cardinals will win

• Louisville has won each of its last 13 games at KFC Yum! Center.
• Kentucky has lost four of its last five games against AP-ranked opponents.

Total Points Facts

• Each of Kentucky’s last 11 games have produced a total of 174 or fewer points.
• Eighty-nine of Louisville’s last 91 games against AP-ranked opponents have produced a total of 173 or fewer points.

Kentucky Wildcats vs. Louisville Cardinals Prediction

I’m on Kentucky and the points here. I get the case to be made for Louisville in a revenge spot at home, but we saw Louisville last year blow out a couple of inferior opponents and then struggle against Tennessee, and other top-tier teams at home before figuring things out in ACC Play. I think even if Louisville gets the win here, I think it could be close. I’ll go with the points and Kentucky here.