Iowa State vs Arizona Prediction Football Picks Today 9/27/25

The Arizona Wildcats and Iowa State Cyclones meet Saturday in college football action at Jack Trice Stadium. Here’s a Iowa State vs Arizona Prediction. This article will include a Iowa State vs Arizona Pick.

Arizona Wildcats Betting Preview

The Arizona Wildcats beat Weber State and Kansas State, and plays Oklahoma State next. The Arizona Wildcats have won 4 of their last 6 games. Noah Fifita is completing 59 percent of his passes for 712 yards, 6 touchdowns, and 0 interceptions. Javin Whatley and Luke Wysong have combined for 334 receiving yards and 2 touchdowns, while Brandon Phelps has 5 receptions.

The Arizona Wildcats ground game is averaging 189 yards per contest, and Ismail Mahdi leads the way with 263 yards and 1 touchdown. Defensively, Arizona is allowing 8.7 points and 222.3 yards per game. Genesis Smith leads the Arizona Wildcats with 19 tackles, Chase Kennedy has 2 sacks and Gavin Hunter has 1 interception.

Iowa State Cyclones Betting Preview

The Iowa State Cyclones beat Arkansas State and Iowa, and they play Cincinnati next. Iowa State has won 8 of its last 9 games. Rocco Becht is completing 65 percent of his passes for 860 yards, 7 touchdowns, and 1 interception. Brett Eskildsen and Gabe Burkle have combined for 311 receiving yards and 2 touchdowns, while Xavier Townsend has 7 receptions.

The Iowa State Cyclones ground game is averaging 161 yards per contest, and Carson Hansen leads the way with 252 yards on 54 carries. Defensively, Iowa State is allowing 14.3 points and 297 yards per game. Marcus Neal Jr. leads the Iowa State Cyclones with 29 tackles, Tamatoa McDonough has 2 sacks and Jeremiah Cooper has 1 interception.

Arizona Wildcats @ Iowa State Cyclones Betting Trends: Week 5

Why the Iowa State Cyclones will win

• Iowa State has won each of its last six games against non-AP-ranked teams.
• Arizona has lost nine of its last 10 September games against AP-ranked teams.
• The home team has covered the spread in six of Arizona’s last seven games.
• Arizona has failed to cover the spread in four of its last five road games.
• Arizona has lost the first half in four of its last five road games against conference opponents.

Why the Arizona Wildcats will win

• Arizona has won four of its last five games in September.
• Arizona has covered the spread in four of its last five September games as an underdog.
• The team ranked 14th in the AP Poll has failed to cover the spread in six of its last eight games.

Total Points Facts

• Each of Arizona’s last 10 games in September have gone UNDER the total points line.
• Four of Iowa State’s last five home games have gone UNDER the total points line.

Iowa State Cyclones Player Prop Facts

• Heading into Week 5, Rocco Becht ranks T10th in the league for TD:INT ratio (7.00) this season.

Arizona Wildcats Player Prop Facts

• Heading into Week 5, Noah Fifita leads Arizona for touchdowns (3) this season.

Matchup/League Facts

• Two of Iowa State’s four games this season have been decided by a margin of three points or less – equal-most amongst FBS teams.
• Iowa State has won the first quarter in each of its last five games – equal-longest active streak in the FBS.
• Arizona ranks 5th among FBS teams for Q4 opponent points per game this season (1.0).
• Arizona ranks T6th among FBS teams for points allowed per game this season (8.7).

Iowa State vs Arizona Prediction

Iowa State is the more proven team at home with the star quarterback, so the line is what it is. However, Iowa State has played a lot of games close to the vest and hasn’t been able to finish drives offensively the way you’d expect. All three games for Iowa State against FBS opponents have been decided by single digits.

Arizona just got a nice home win over Kansas State, is balanced offensively, and has one of the best defenses in the country. Arizona is seventh in total defense and sixth in scoring defense. It doesn’t feel like Arizona is getting much respect. I’ll grab the points.