Pittsburgh vs Central Michigan Prediction Football Picks Today 9/6/25

The Central Michigan Chippewas and the Pitt Panthers meet in week 2 college football action from Acrisure Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Central Michigan Chippewas vs. Pitt Panthers prediction.

Central Michigan Chippewas Recap

The Central Michigan Chippewas come into this game looking to add on to their 16-14 win over the San Jose State Spartans to improve to 1-0 this season. After this game, the Chippewas will head on the road for a game against the Michigan Wolverines.

Chippewas Looking For Big Road Upset

Angel H Flores threw for 59 yards on 3 of 3 passing while Joe Labas threw for 56 yards on 5 of 10 passing. Nahree Biggins added 102 rushing yards on 18 carries while Trey Cornist chipped in 13 carries for 99 yards and a touchdown. Tommy McIntosh led the Chips with 61 receiving yards coming on a pair of receptions in the winning effort. On defense, Kalen Carroll and Dakota Cochran each had a team-high 7 total tackles while Michael Heldman had a sack and Brenden Deasfernandes and Elijah Rikard each had an interception for CMU’s defense in the winning effort. 

Why the Central Michigan Chippewas will win

• Pittsburgh has lost six of its last seven games.
• Central Michigan has covered the spread in five of its last six September games as an underdog.
• Pittsburgh has failed to cover the spread in four of its last five games against non-AP-ranked teams.

Pitt Panthers Recap

The Pitt Panthers come into this game looking to build on their 61-9 rout of Duquesne last time out to start the year 1-0. After this game, Pitt will head on the road for the Backyard Brawl against West Virginia.

Panthers Looking To Carry Forward Success In Week 2

Eli Holstein threw for 215 yards, 4 touchdowns and an interception on 15 of 23 passing while Cole Gonzales threw for 87 yards and a TD on 8 of 15 passing. Desmond Reid rushed for 66 yards and a touchdown on 8 carries while the aforementioned Holstein had 41 rushing yards and Juelz Goff chipped in 31 rushing yards and a score. Bryce Yates led the Panthers with 69 receiving yards and a touchdown while Cataurus Hicks added 4 receptions for 55 yards and 2 TDs and Kenny Johnson had 4 catches for 47 yards and a score. Malachi Thomas chipped in a receiving touchdown as well in the win. On defense, Kyle Louis had a team-high 6 total tackles along with a pair of sacks while Cameron Lindsey and Joey Zelinsky each chipped in a sack as well.

Why the Pittsburgh Panthers will win

• Central Michigan has lost 16 of its last 17 road games in September.
• Pittsburgh has won 18 of its last 20 September home games against non-AP-ranked teams.
• Pittsburgh has covered the spread in each of its last four home games against non-conference opponents.
• Central Michigan has failed to cover the spread in three of its last four road games against opponents from the Atlantic Coast Conference.

Total Points Facts

• Each of Pittsburgh’s last 11 September games as a favorite have gone OVER the total points line.
• Four of Central Michigan’s last five games have gone UNDER the total points line.

Central Michigan Chippewas vs. Pitt Panthers Prediction

I’m on Pitt here. I just think that there’s a clear gap in talent between these two teams and while I’m not necessarily high on the prospects of the Pitt Panthers long term, I do think that Pitt’s going to be more than good enough here to deal with what I feel is a lacklustre Central Michigan team and offense in general. I have this game finishing closer to four scores than just over three where this line’s been at so give me Pitt laying the big number.