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Stanford vs BYU Prediction 9/6/25 College Football Picks Today

Stanford vs BYU
September 6, 2025 10:15 pm EDT
The Line: BYU -20.5 / Over/Under: 46
(Get latest betting odds)

In this article, we will formulate a Stanford vs BYU Prediction for this College Football Week 2 game on Saturday, September 6th at the LaVell Edwards Stadium. Let’s take a look at the prediction for this College Football matchup.

BYU Cougars Preview

The Cougars are coming off a 69-0 home victory over Portland State in their season opener. BYU outgained their opponents by 606-53 yards. They had 12/18 completed passes, 138 passing yards, 436 rushing yards, with turnovers being 1-1. The Cougars went 6-10 in third down efficiency and had 5-55 penalties.

Bear Bachmeier had 7/11 passes, a team-high 97 passing yards and three touchdowns. LJ Martin added a team-high 131 rushing yards, while Carsen Ryan caught 2 passes for 47 yards and one touchdown. Defensively, Talan Alfrey had three total tackles, all of them solo, while Anisi Purcell and Choe Bryant-Strother had one sack each. BYU did not have any interceptions in this game.

Stanford Cardinal Preview

The Cardinal are coming off a 20-23 road defeat in Hawaii in their season opener. Stanford got outgained by their opponents by 306-286 yards. They had 15/30 completed passes, 109 passing yards, 177 rushing yards, with both teams being 1-1 in turnovers. The Cardinal went 8-17 in third down efficiency and had 7-70 penalties.

Ben Gulbranson had 15/30 passes, a team-high 109 passing yards but also threw one interception. Micah Ford added a team-high 113 rushing yards and one touchdown, while Tiger Bachmeier caught 6 passes for 61 yards. Defensively, Tristan Sinclair had 8 total tackles, 4 of them solo, while Jaxson Moi had one sack. Stanford did not have any interceptions in this game.

Stanford vs BYU Prediction

In their only previous meeting back in 2022, BYU won 35-26 on the road, covering the spread, as the game went over the point total.

In this Stanford vs BYU Prediction, BYU is coming in as -20.5-point road favorites, with the total set at 46 points. Both teams are coming off opposite outcomes in their opening games of the season. BYU was almost perfect at home last season with a 5-1 record, and were very strong against the spread, with a 7-4-1 ATS. On the flip side, Stanford was terrible on the road, with a 1-5 road record, and struggled to cover spread, going for 4-7-1 against the spread. BYU was dominating in their season opener, winning by 69-0, and are playing their second straight game at home, while Stanford had to travel all the way from Hawaii. Take the BYU Cougars and lay the points in this one.

Nikos Lagouretos's Free Pick: BYU -20.5

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