Troy vs Clemson Prediction 9/6/25 College Football Picks Today

In this article, we will formulate a Troy vs Clemson Prediction for this College Football Week 2 game on Saturday, September 6^th at the Memorial Stadium (Clemson, SC). Let’s take a look at the prediction for this College Football matchup.

Clemson Tigers Preview

The Tigers are coming off a 10-17 home defeat by LSU in their season opener. Clemson got outgained by their opponents by 356-261 yards. They had 19/38 completed passes, 230 passing yards, 31 rushing yards, with turnovers being 1-0. The Tigers went 3-13 in third down efficiency and had 6-57 penalties.
Cade Klubnik had 19/38 passes, a team-high 230 passing yards. Adam Randall added a team-high 20 rushing yards, while Bryant Wesco Jr. caught 6 passes for 72 yards. Defensively, Sammy Brown had 12 total tackles, while T.J. Parker had one sack. Clemson had no interceptions.

Troy Trojans Preview

The Trojans are coming off a 38-20 home victory over Nicholls in their season opener. Troy outgained their opponents by 416-249 yards. They had 14/24 completed passes, 144 passing yards, 272 rushing yards, with turnovers being 0-1. The Trojans went 9-15 in third down efficiency and had 8-100 penalties.
Goose Crowder had 14/24 passes, a team-high 144 passing yards. Tae Meadows added a team-high 23 rushing yards, while Roman Mothershed caught 6 passes for 82 yards. Defensively, Luke Hodge had 12 total tackles, while Julian Peterson had four sacks. Troy had no interceptions.

Why the Clemson Tigers will win

• Clemson has won 42 of its last 44 home games against non-AP-ranked teams.
• Troy has lost eight of its last nine games against AP-ranked teams.
• Clemson has covered the spread in each of its last five September games against non-AP-ranked teams.
• Troy has failed to cover the spread in three of its last four September games against AP-ranked teams.
• Clemson has won the first quarter in 13 of its last 15 games against non-conference opponents at Memorial Stadium (Clemson).
• Clemson has won the first half in 32 of its last 33 games against non-conference opponents at Memorial Stadium (Clemson).

Why the Troy Trojans will win

• The team ranked 8th in the AP Poll has lost each of its last four games.
• Troy has won four of its last five games.
• The team ranked 8th in the AP Poll has failed to cover the spread in seven of its last eight games.
• Troy has covered the spread in eight of its last 10 games against teams from South Carolina.

Total Points Facts

• Eight of Troy’s last nine road openers have gone UNDER the total points line.
• Five of Clemson’s last six September home games against non-AP-ranked teams have gone OVER the total points line.

Matchup/League Facts

• Clemson ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).
• One of Clemson’s one games this season have been decided by a margin of seven points or less – equal-most amongst FBS teams.
• Troy ranks 1st among FBS teams for Q4 points per game this season (28.0).
• Troy ranks T1st among FBS teams for Q1 opponent points per game this season (0.0).

Troy vs Clemson Prediction

Clemson has won both meetings against Troy, with the most recent one being back in 2016, where Clemson won 30-24 at home.

In this Troy vs Clemson Prediction, Clemson is coming in as -31.5-point road favorites, with the total set at 51.5 points. Both teams are coming off opposite outcomes in their opening games of the season, but the opposition was on a completely different level. Clemson was a strong 5-2 last season, but just 5-6 against the spread, while Troy was terrible on the road, with a 1-5 road record and just 6-6 against the spread. Clemson is playing their second straight game at home, after losing their season opener, and I don’t expect them to lose two in a row in front of their home crowd. Take the Clemson Tigers and lay the points at home.