Draftkings NFL Showdown Picks: 49ers vs. Rams 10/2/25
San Francisco 49ers vs. Los Angeles Rams
October 2, 2025 8:15 pm EDT
This Thursday night, the NFL presents Draftkings football fans with a regular season matchup featuring the San Francisco 49ers and the Los Angeles Rams. Let’s take a look at this game from a DFS perspective.
Before we dive into the San Francisco 49ers vs. Los Angeles Rams game let’s review the rules for the Draftkings single game showdown contest.
Draftkings Single Game Showdown Contest Rules
You have $50,000 to utilize on five players from either team. However, one of those players will be designated as your team captain. The captain accumulates 1.5 times the standard fantasy points. Additionally, the captain is 1.5 times the standard cost of the flex position.
The remaining four players in your lineup will receive the standard fantasy points. Having stated that, it is highly important for you to identify the correct player for your captain position if you hope to win a large field DFS GPP (guaranteed prize pool) showdown contest.
If you have additional questions regarding the rules for the single game showdown contest, I recommend that you check out the Draftkings website for more details.
*I recommend that all readers review the starting lineups for both teams prior to setting your DFS lineup for this one game slate.
Here are my Draftkings picks for this Thursday night’s 49ers vs. Rams matchup.
Draftkings NFL Showdown Picks
Captain-Christian McCaffrey, Running Back, San Francisco 49ers $11,400
Veteran running back Christian McCaffrey has certainly been a standout performer for the San Francisco 49ers in 2025. With that said, how has McCaffrey performed from a data perspective this season? Let’s review McCaffrey’s relevant key player game data from the 2025 NFL regular season to better shed light on the talented running back’s overall contributions to his team.
In the four games that running back Christian McCaffrey has played for the San Francisco 49ers in the 2025 NFL regular season, McCaffrey has amassed 225 rushing yards, 31 receptions, 305 receiving yards and two receiving touchdowns.
Looking at the data just presented more closely, in the four games that McCaffrey has played this season, McCaffrey has averaged a rather impressive 24.1 Draftkings points.
More recently, in the San Francisco 49ers 16-15 win over the Arizona Cardinals two weeks ago, San Francisco running back Christian McCaffrey played exceptionally well. Let me be more specific. In the 49ers defeat of the Cardinals, McCaffrey tallied 52 rushing yards, ten receptions and 88 receiving yards.
What did we learn from the data just presented? The data clearly illustrates that Christian McCaffrey can post a high number of DFS points on any given night. Additionally, the data indicates that McCaffrey has a massive usage rate within the San Francisco 49ers offense. Having stated that, I fully expect that trend to continue in this Thursday night’s matchup with the Los Angeles Rams.
As I noted in the rules section above, selecting the correct player at the captain position for a Draftkings NFL Football showdown lineup is absolutely vital if you hope to win a large field GPP (guaranteed prize pool) DFS contest. Keep that in mind as you construct your lineups.
In my view, Christian McCaffrey is the most likely player to post the most Draftkings points in this NFL regular season game. For that specific reason, I am rolling with San Francisco 49ers running back Christian McCaffrey at the captain position for this one game NFL DFS slate.
Flex plays I like to play well in this NFL regular season contest (Draftkings price noted): Puka Nacua, Wide Receiver (Los Angeles Rams) $11,600: Ricky Pearsall, Wide Receiver (San Francisco 49ers) $7,400: Tyler Higbee, Tight (Los Angeles Rams) $2,800.
