Draftkings NFL Showdown Picks: Jaguars vs. 49ers 9/28/25
Jacksonville Jaguars vs. San Francisco 49ers
September 28, 2025 4:05 pm EDT
Later today, the NFL presents Draftkings football fans with a regular season matchup featuring the Jacksonville Jaguars and the San Francisco 49ers. Let’s take a look at this game from a DFS perspective.
Before we dive into the Jacksonville Jaguars vs. San Francisco 49ers game let’s review the rules for the Draftkings single game showdown contest.
Draftkings Single Game Showdown Contest Rules
You have $50,000 to utilize on five players from either team. However, one of those players will be designated as your team captain. The captain accumulates 1.5 times the standard fantasy points. Additionally, the captain is 1.5 times the standard cost of the flex position.
The remaining four players in your lineup will receive the standard fantasy points. Having stated that, it is highly important for you to identify the correct player for your captain position if you hope to win a large field DFS GPP (guaranteed prize pool) showdown contest.
If you have additional questions regarding the rules for the single game showdown contest, I recommend that you check out the Draftkings website for more details.
*I recommend that all readers review the starting lineups for both teams prior to setting your DFS lineup for this one game slate.
Here are my Draftkings picks for this afternoon’s Jaguars vs. 49ers matchup.
Draftkings NFL Showdown Picks
Captain-Christian McCaffrey, Running Back, San Francisco 49ers $12,400
Veteran running back Christian McCaffrey has certainly been a standout performer for the San Francisco 49ers in 2025. With that said, how has McCaffrey performed from a data perspective this season? Let’s review McCaffrey’s relevant key player game data from the 2025 NFL regular season to better shed light on the talented running back’s overall contributions to his team.
In the three games that running back Christian McCaffrey has played for the San Francisco 49ers in the 2025 NFL regular season, McCaffrey has amassed 176 rushing yards, 25 receptions, 213 receiving yards and one receiving touchdown.
Looking at the data just presented more closely, in the three games that McCaffrey has played this season, McCaffrey has averaged a robust 23.3 Draftkings points.
What did we learn from the data just presented? The data clearly illustrates that Christian McCaffrey can post a high number of DFS points on any given night. Additionally, the data indicates that McCaffrey has a massive usage rate within the San Francisco 49ers offense. Having stated that, I fully expect that trend to continue in this afternoon’s matchup with the Jacksonville Jaguars.
As I noted in the rules section above, selecting the correct player at the captain position for a Draftkings NFL Football showdown lineup is absolutely vital if you hope to win a large field GPP (guaranteed prize pool) DFS contest. Keep that in mind as you construct your lineups.
In my view, Christian McCaffrey is the most likely player to post the most Draftkings points in this NFL regular season game. For that specific reason, I am rolling with San Francisco 49ers running back Christian McCaffrey at the captain position for this one game NFL DFS slate.
Flex Plays
Trevor Lawrence, Quarterback, Jacksonville Jaguars $9,600
In the three games that quarterback Trevor Lawrence has played for the Jacksonville Jaguars in the 2025 NFL regular season, Lawrence has tallied 671 passing yards and four receiving touchdowns.
More recently, in the Cincinnati Bengals 31-27 win over the Jacksonville Jaguars two weeks ago, Jacksonville quarterback Trevor Lawrence compiled 271 passing yards and three receiving touchdowns.
Flex plays I like to play well in this NFL regular season contest (Draftkings price noted): Brock Purdy, Quarterback (San Francisco 49ers) $10,000: Bhayshul Tuten, Running Back (Jacksonville Jaguars) $5,400: Parker Washington, Wide Receiver (Jacksonville Jaguars) $3,700.
