FanDuel Best MLB DFS Picks: Cardinals vs. Cubs 9/26/25

Major League Baseball presents FanDuel baseball fans with a National League matchup featuring the St. Louis Cardinals and the Chicago Cubs. Let’s take a look at this MLB game from a DFS perspective.

Before we dive into the St. Louis Cardinals vs. Chicago Cubs game let’s review the rules for the FanDuel single game showdown contest.

FanDuel Single Game Contest Rules

Here are the FanDuel single game contest rules. You have $60,000 to utilize on five players from either team. However, one of those players will be designated as your team MVP. The MVP accumulates 1.5x times the standard FanDuel fantasy points value. Additionally, the MVP is 1.5 times the standard cost of the flex position.

The remaining five players in your lineup will be flex plays. The five flex positions will receive the standard FanDuel points value. Having stated that, it is highly important for you to identify the correct player for your MVP position if you hope to win a large field GPP (guaranteed prize pool) FanDuel single game contest.

If you have additional questions regarding the rules for the single game contest, I highly recommend that you check out the FanDuel website for more details.

*It should be noted that FanDuel does not utilize the pitcher position in single game MLB contests. Having stated that, only batters are available for single game MLB lineups on the FanDuel platform.

Here are my FanDuel picks for this afternoon’s Cardinals vs. Cubs matchup.

FanDuel MLB DFS Picks

MVP-Alec Burleson, Outfielder, St. Louis Cardinals $9,200

On Friday afternoon, Major League Baseball presents the opening game of a three-game National League series featuring the St. Louis Cardinals and the Chicago Cubs.

How are these two teams playing entering today’s MLB game? The Chicago Cubs arrive at the first game of this three-game series with the St. Louis Cardinals playing below average baseball. The Cubs have lost six of the team’s last seven games played in the 2025 MLB regular season, including a 1-0 shutout loss to the Cincinnati Reds five days ago.

In direct contrast to the Chicago Cubs, the St. Louis Cardinals are currently playing good baseball entering this afternoon’s game. The Cardinals have won four of the team’s last six games played in the 2025 MLB regular season, including a 7-1 victory over the Milwaukee Brewers last week.

Now that we have identified how both of these teams are currently playing let’s turn our attention to today’s contest. Talented outfielder Alec Burleson has been a solid contributor for the St. Louis Cardinals this season. With that said, how has the veteran outfielder performed from a statistical perspective? Let’s examine Burleson’s relevant game data from the 2025 MLB regular season to answer that question.

In the 137 games that Alec Burleson has played for the St. Louis Cardinals in the 2025 MLB regular season, Burleson has compiled a .293 batting average, 18 home runs, 38 walks, 69 RBIs (runs batted in), 54 runs scored, five stolen bases, a .345 OBP (On-Base Percentage) and an .810 OPS (On-Base Plus Slugging).

What did we learn from the data just presented? Clearly, Alec Burleson can post a high number of DFS points on any given night.

In my view, Alec Burleson’s reasonable FanDuel price of $9,200 presents outstanding fantasy value. For that specific reason, I am rolling with St. Louis Cardinals outfielder Alec Burleson at the MVP position for this one game MLB DFS slate.

Flex plays I like in this MLB regular season game (FanDuel price noted): Pete Crow-Armstrong, Outfielder (Chicago Cubs) $12,000: Michael Busch, First Baseman (Chicago Cubs) $10,200: Ivan Herrera, Catcher (St. Louis Cardinals) $12,800.