Cardinals vs Cubs Prediction 9/26/25 MLB Picks Today

In this article, we will formulate a Cardinals vs Cubs Prediction for this MLB game on Friday, September 26^th at the Wrigley Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have an 89-70 record this season and are sitting on the second place of the NL Central. The Cubs have a 47-31 home record and are 72-74 in over/under. They are coming off a 5-8 home defeat by the Mets, and are 1-6 in their last 7 games. Over is 4-1-1 in their last 6 games.

The Cubs have a .249 batting average this season, .320 OBP and .427 Slugging percentage. Chicago’s pitching staff has a 3.84 ERA and 1.18 WHIP. Nico Hoerner leads the Cubs with 175 hits, and he is the team’s best hitter with a .299 batting average. Seiya Suzuki leads the team in RBI, with 97, while Michael Busch adds a team-high 31 home runs.

Colin Rea (R) is the projected starting pitcher for the Cubs, and he has a 10-7 record, 4.10 ERA and 1.28 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 78-81 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 34-44 road record and are 79-72 in over/under. They are coming off a 3-4 road defeat by the Giants, that ended their three-game winning streak. Under is 5-3 in their last 8 games.

The Cardinals have a .246 batting average this season, .318 OBP and .380 Slugging percentage. Saint Louis’ pitching staff has a 4.23 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 144 hits, and he is the team’s best hitter with a .293 batting average. Wilson Contreras leads the team in RBI, with 80, adding a team-high 20 home runs.

Miles Mikolas (R) is the projected starting pitcher for the Cardinals, and he has an 8-10 record, 4.76 ERA and 1.33 WHIP.

St. Louis Cardinals @ the Chicago Cubs Betting Trends: September 26, 2025

• Probable Starting Pitcher: Colin Rea      Record this season: 10-7      ERA: 4.10
• Home Record: 5-3
• Last 5 against Cardinals: 2-0

Why the Chicago Cubs will win

• The Cubs have won seven of their last eight games against teams that held a losing record.
• The Cardinals have lost six of their last seven games at Wrigley Field against teams that held a winning record.
• The Cubs have covered the run line in seven of their last eight games against teams that held a losing record.
• The Cardinals have failed to cover the run line in six of their last seven games at Wrigley Field against teams that held a winning record.
• The Cardinals have trailed after 5 innings in seven of their last eight road day games.
• The Cubs have led after 3 innings in six of their last seven games as home favorites against National League opponents.

• Probable Starting Pitcher: Miles Mikolas      Record this season: 8-10      ERA: 4.76
• Road Record: 4-6
• Last 5 against Cubs: 1-3

Why the St. Louis Cardinals will win

• The underdogs have won each of the Cardinals’ last four games.
• The Cubs have lost three of their last four games as home favorites against National League opponents.
• The Cubs have failed to cover the run line each of their last nine Friday day games against NL Central opponents that held a losing record.
• The underdogs have covered the run line in each of the Cardinals’ last six games.
• The Cardinals have led after 3 innings in six of their last seven games as underdogs against NL Central opponents.
• The Cardinals have led after 5 innings in seven of their last eight games against NL Central opponents that held a winning record.

Total Runs Facts

• Each of the Cubs’ last four games as favorites have gone OVER the total runs line.
• Each of the Cardinals’ last four day games against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Cubs’ last nine games as home favorites against NL Central opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Cardinals’ last five games at Wrigley Field.

Chicago Cubs Player Prop Facts

• Ian Happ has recorded a Double in each of the Cubs’ last three games.
• Dansby Swanson has recorded at least one hit in each of the Cubs’ last nine games against the Cardinals.
• Carson Kelly has hit at least one home run in three of his last four home appearances against former teams.
• Nico Hoerner ranks T5th in the league in Hits (175) this season.

St. Louis Cardinals Player Prop Facts

• Brendan Donovan has recorded at least one Double in four of his last five appearances.
• Miles Mikolas has recorded four or more strikeouts in each of his last six appearances in day games against NL teams that held a winning record.
• Nolan Arenado has recorded at least one hit in each of his last 10 appearances with the Cardinals as road underdogs against the Cubs.
• Nolan Gorman has hit a home run in three of his last eight appearances against the Cubs.
• Victor Scott II ranks T10th in the league in Steals (33) this season.

Matchup/League Facts

• The Cubs rank 1st in the league for walks allowed this season (399).
• The Cubs rank 3rd in the league for steals this season (159).
• The Cardinals rank 30th in the league for triples this season (8).
• The Cardinals rank 29th in the league for home runs this season (146).

Cardinals vs Cubs Prediction

The Cubs are 5-3 in their last 8 head-to-head meetings against the Cardinals, and are 2-1 in their last 3 meetings in Chicago. Over is 4-2 in their last 6 meetings.

In this Cardinals vs Cubs Prediction, the Cubs are coming as -180 home favorites. Both teams have nothing to play for, and I don’t trust either pitcher in this matchup, as they have both been shaky this season. Mikolas has been terrible on the road for the Cardinals, and was torched in his only start against the Cubs this season with 8 earned runs. On the flip side, Rea has been great against the Cardinals this season, with just two earned runs in 12.2 innings pitched in his two starts against them. Chicago also has a superior offense, and I expect them to get the job done at home in this one.