FanDuel Best MLB DFS Picks: Padres vs. Astros 4/20/25

Major League Baseball presents FanDuel baseball fans with a National League matchup featuring the San Diego Padres and the Houston Astros. Let’s take a look at this MLB game from a DFS perspective.

Before we dive into the San Diego Padres vs. Houston Astros game let’s review the rules for the FanDuel single game showdown contest.

FanDuel Single Game Contest Rules

Here are the FanDuel single game contest rules. You have $60,000 to utilize on five players from either team. However, one of those players will be designated as your team MVP. The MVP accumulates 1.5x times the standard FanDuel fantasy points value. Additionally, the MVP is 1.5 times the standard cost of the flex position.

The remaining five players in your lineup will be flex plays. The five flex positions will receive the standard FanDuel points value. Having stated that, it is highly important for you to identify the correct player for your MVP position if you hope to win a large field GPP (guaranteed prize pool) FanDuel single game contest.

If you have additional questions regarding the rules for the single game contest, I highly recommend that you check out the FanDuel website for more details.

*It should be noted that FanDuel does not utilize the pitcher position in single game MLB contests. Having stated that, only batters are available for single game MLB lineups on the FanDuel platform.

Here are my FanDuel picks for tonight’s San Diego Padres vs. Houston Astros matchup.

FanDuel MLB Player Selections

MVP-Fernando Tatis Jr., Outfielder, San Diego Padres $14,600

On Sunday night, Major League Baseball presents the final game of a three-game National League series featuring the San Diego Padres and the Houston Astros.

How are these two teams playing entering tonight’s MLB game? The San Diego Padres arrive at the third game of this three-game series with the Houston Astros playing below average baseball. More specifically, the San Diego Padres have lost three of the team’s last four games played in the 2025 MLB regular season, including a 2-1 loss to the Chicago Cubs earlier this week.

In direct contrast to the San Diego Padres, the Houston Astros are currently playing good baseball entering this evening’s game. The Astros have won three of the team’s last four games played in the 2025 MLB regular season, including a 2-0 shutout win over the St. Louis Cardinals five days ago.

Now that we have ascertained how both of these teams are currently playing let’s shift our attention to this evening’s contest. Outfielder Fernando Tatis Jr. has been an essential part of the San Diego Padres starting lineup this season. With that said, how has the veteran outfielder performed from a statistical standpoint? Let’s examine Tatis Jr.’s relevant game data from the 2025 MLB regular season to answer that question.

In 19 games that San Diego Padres outfielder Fernando Tatis Jr. has played in the 2025 MLB regular season, Tatis Jr. has compiled a rather impressive .350 batting average, 27 hits, seven home runs, 11 walks, 15 RBIs (runs batted in) and 19 runs scored.

Last night, in the Houston Astros 3-2 win over the San Diego Padres, San Diego outfielder Fernando Tatis Jr. played at a high level. In the Astros victory over the Padres, Tatis Jr. amassed two hits, one RBI, two runs scored and one home run. It should also be mentioned that in the Astros defeat of the Padres, Tatis Jr. compiled a massive 30.9 FanDuel points.

In my view, Fernando Tatis Jr. is the most likely player to accumulate the most FanDuel points in this MLB game. With that said, I am rolling with San Diego Padres outfielder Fernando Tatis Jr. at the MVP position for this one game MLB DFS slate.

Flex plays I like in this game (FanDuel price noted): Yordan Alvarez, Outfielder (Houston Astros) $10,600: Jose Altuve, Second Baseman (Houston Astros) $11,200: Cam Smith, Outfielder (Houston Astros) $8,400.