FanDuel Best MLB DFS Picks: Reds vs. Brewers 9/26/25

Major League Baseball presents FanDuel baseball fans with a National League matchup featuring the Cincinnati Reds and the Milwaukee Brewers. Let’s take a look at this MLB game from a DFS perspective.

Before we dive into the Cincinnati Reds vs. Milwaukee Brewers game let’s review the rules for the FanDuel single game showdown contest.

FanDuel Single Game Contest Rules

Here are the FanDuel single game contest rules. You have $60,000 to utilize on five players from either team. However, one of those players will be designated as your team MVP. The MVP accumulates 1.5x times the standard FanDuel fantasy points value. Additionally, the MVP is 1.5 times the standard cost of the flex position.

The remaining five players in your lineup will be flex plays. The five flex positions will receive the standard FanDuel points value. Having stated that, it is highly important for you to identify the correct player for your MVP position if you hope to win a large field GPP (guaranteed prize pool) FanDuel single game contest.

If you have additional questions regarding the rules for the single game contest, I highly recommend that you check out the FanDuel website for more details.

*It should be noted that FanDuel does not utilize the pitcher position in single game MLB contests. Having stated that, only batters are available for single game MLB lineups on the FanDuel platform.

Here are my FanDuel picks for tonight’s Cincinnati Reds vs. Milwaukee Brewers matchup.

FanDuel MLB DFS Picks

MVP-Elly De La Cruz, Shortstop, Cincinnati Reds $13,200

On Friday night, Major League Baseball presents the opening game of a three-game National League series featuring the Cincinnati Reds and the Milwaukee Brewers.

How are these two teams playing entering today’s MLB contest? The Cincinnati Reds arrive at the first game of this three-game series with the Milwaukee Brewers playing good baseball. The Reds have won six of the team’s last eight games played in the 2025 MLB regular season, including a 1-0 shutout victory over the Chicago Cubs five days ago.

In direct contrast to the Cincinnati Reds, the Milwaukee Brewers are playing below average baseball entering the opening game of this National League series. Let me be more specific. The Brewers have lost four of the team’s last six games played in the 2025 MLB regular season, including a 7-1 loss to the St. Louis Cardinals last week.

Now that we have determined how both of these teams are currently playing let’s turn our attention to this evening’s contest. Veteran shortstop Elly De La Cruz has certainly been a standout performer for the Cincinnati Reds starting lineup this season. With that said, how has the talented shortstop performed from a statistical standpoint? Let’s examine De La Cruz’s relevant game data from the 2025 MLB regular season to answer that question.

In the 159 games that Elly De La Cruz has played for the Cincinnati Reds in the 2025 MLB regular season, De La Cruz has compiled a .264 batting average, 21 home runs, 66 walks, 85 RBIs (runs batted in), 36 stolen bases (sixth in MLB), 101 runs scored (11th in MLB), a .337 OBP (On-Base Percentage) and a .776 OPS (On-Base Plus Slugging).

In my opinion, Elly Da La Cruz is the most likely player to amass the most FanDuel points in this MLB game. For that specific reason, I am rolling with Cincinnati Reds shortstop Elly Da La Cruz at the MVP position for this MLB DFS contest.

Flex plays I like in this MLB regular season game (FanDuel price noted): Jackson Chourio, Outfielder (Milwaukee Brewers) $12,600: TJ Friedl, Outfielder (Cincinnati Reds) $6,400: Spencer Steer, Outfielder (Cincinnati Reds) $7,400.