Angels vs Brewers Prediction 9/17/25 MLB Picks Today

In this article, we will formulate an Angels vs Brewers Prediction for this MLB game on Wednesday, September 17^th at the American Family Field in the second game of this series, with the Brewers having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 92-59 record this season and are sitting on the first place of the NL Central. They have a 49-27 home record and are 73-73 in over/under. They are coming off a 9-2 home victory over the Angels, and are 3-1 in their last 4 games. Over is 6-2 in their last 8 games and are playing the Cardinals and the Padres next.

The Brewers have a .261 batting average this season, .334 OBP and .409 Slugging percentage. Milwaukee’s pitching staff has a 3.62 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 157 hits, while Christian Yelich leads the team in RBI, with 99, adding a team-high 29 home runs. Sal Frelick is the team’s best hitter with a .296 batting average.

Brandon Woodruff (R) is the projected starting pitcher for the Brewers, and he has a 6-2 record, 3.32 ERA and 0.96 WHIP.

Los Angeles Angels Preview

The Los Angeles Angels have a 69-82 record this season and are sitting on the 4^th place of the AL West. The Angels have a 32-44 road record and 83-65 in over/under They are coming off a 2-9 road defeat by the Mariners, and have five consecutive losses. Over is 8-3 in their last 11 games and are playing the Rockies and the Royals next.

The Angels have a .227 batting average this season, .301 OBP and .399 Slugging percentage. LA’s pitching staff has a 4.86 ERA and 1.44 WHIP. Zach Neto leads the Angels with 129 hits, while Nolan Schanuel is the team’s best hitter with a .266 batting average. Taylor Ward leads the team with 98 RBI, while Jo Adell adds a team-high 36 home runs.

Jose Soriano (R) is the projected starting pitcher for the Angels, and he has a 10-10 record, 4.13 ERA and 1.38 WHIP.

Los Angeles Angels @ Milwaukee Brewers Betting Trends: September 17, 2025

• Probable Starting Pitcher: Brandon Woodruff      Record this season: 6-2      ERA: 3.32
• Home Record: 2-0
• Last 5 against Angels: 0-1

Why the Milwaukee Brewers will win

• The home team has won each of the Angels’ last seven games.
• The Angels have lost each of their last six road games.
• The Angels have failed to cover the run line in each of their last seven night games against NL Central opponents following a loss.
• The Brewers have covered the run line in seven of their last eight night games against AL West opponents that held a losing record.
• The Angels have lost the first inning in each of their last three games.
• The Angels have trailed after 5 innings in each of their last seven games as underdogs against National League opponents.
• The Brewers have led after 3 innings in each of their last six games as home favorites against AL West opponents.

• Probable Starting Pitcher: Jose Soriano      Record this season: 10-10      ERA: 4.13
• Road Record: 8-2
• Last 5 against Brewers: –

Why the Los Angeles Angels will win

• The Brewers have lost five of their last six games as home favorites after playing the previous day.
• The Angels have won 12 of their last 17 games as road underdogs against National League opponents following a loss.
• The Brewers have failed to cover the run line in each of their last seven home games following a win.
• The underdogs have covered the run line in eight of the Brewers’ last 10 games at American Family Field.
• The Brewers have trailed after 5 innings in five of their last six games as favorites against American League opponents.

Total Runs Facts

• Each of the Angels’ last four road games against NL Central opponents have gone OVER the total runs line.
• Five of the Brewers’ last six games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Angels’ last 10 games as underdogs against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Brewers’ last 10 night games against American League opponents.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in each of the Brewers’ last two night games against AL opponents that held a losing record.
• Brandon Woodruff has recorded eight strikeouts in three of his last four appearances against opponents that held a losing record.
• Brandon Woodruff has recorded a win in each of his last six appearances in night games against teams that held a losing record.
• Sal Frelick has recorded a Double in four of his last five appearances in night games against AL West teams that held a losing record.
• Sal Frelick has recorded at least one hit in each of his last 11 appearances with the Brewers as home favorites against AL opponents.
• Sal Frelick ranks 10th amongst qualified players for Batting Average (.296) this season.

Los Angeles Angels Player Prop Facts

• Jo Adell has hit a home run in three of his last four appearances after playing the previous day.
• Nolan Schanuel has recorded two or more hits in each of his last three appearances with the Angels as road underdogs.
• Jo Adell ranks 8th in the league in Home Runs (36) this season.

Matchup/League Facts

• The Brewers rank 2nd in the league for batting average this season (.261).
• The Brewers rank 2nd in the league for on-base percentage this season (.334).
• The Angels rank 30th in the league for doubles this season (202).
• The Angels rank 30th in the league for strikeouts against this season (1510).

Angels vs Brewers Prediction

The Brewers are 5-2 in their last 7 meetings against the Angels, and are 3-2 in their last 5 meetings Milwaukee. Under is 5-2-1 in their last 8 meetings.

In this Angels vs Brewers Prediction, the Brewers are coming as -200 home favorites. The Brewers have once again the pitching advantage in this matchup, as Brandon Woodruff takes the mound, and he has been elite this season, coming off a shutout start against the Pirates. On the flip side, Soriano has given up 11 runs in his last two starts for the Angels, who also have the third-worst bullpen in baseball. Milwaukee has the third-best offense in the league, and I expect them to dominate this game once again and cover the runline.