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Angels vs Orioles Prediction 5/11/25 MLB Picks Today

Baltimore Orioles (14-24) vs. LA Angels (16-22)
May 11, 2025 4:07 pm EDT
The Line: LA Angels +120 / Baltimore Orioles -142; Over/Under: 9
(Get latest betting odds)

The Baltimore Orioles and the Los Angeles Angels meet Sunday in MLB action from Angel Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Angels vs Orioles Prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Zach Eflin for the start here, and Eflin is 2-1 with a 3.00 ERA and 8 strikeouts this season. Tyler Anderson will get the start for the Angels here and is 2-0 with a 2.68 ERA and 34 strikeouts this season. In his career, Anderson is 0-1 with a 4.50 ERA and 9 strikeouts against the Orioles.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to bounce back from a 5-2 loss at the hands of the Angels last time out to slip to 14-24 on the year. After this series, the Orioles will have a rematch series against the Minnesota Twins at home.

O’s Lose 6 Of Their Last 7

Cedric Mullins has 28 hits so far this season, as well as 5 doubles, 7 home runs, and 21 RBIs with 5 stolen bases and a .220 batting average, while Adley Rutschman has 25 hits with 4 doubles, 4 homers, and 10 RBIs. Ryan Mountcastle has 27 hits with 8 doubles, and Tyler O’Neill has 15 hits with 3 doubles, a triple, and 2 homers with 10 RBIs. Jordan Westburg added 4 home runs, and Gunnar Henderson has a team-high 35 strikeouts as well this season. Ryan O’Hearn also chipped in 30 hits with 4 doubles and 7 home runs with 14 RBIs, and Heston Kjerstad added 3 homers and 13 RBIs.

Why the Baltimore Orioles will win

  • The Angels have lost each of their last seven day games against AL East opponents following a win.
  • The Orioles have won each of their last four road games against AL West opponents following a loss.
  • The Angels have failed to cover the run line in each of their last five day games against American League opponents.
  • The Orioles have covered the run line in five of their last six games against AL West opponents that held a losing record.

Baltimore Orioles Player Prop Facts

  • Ramon Laureano has hit a home run in three of his last four appearances at Angel Stadium of Anaheim against AL opponents that held a losing record.
  • Zach Eflin has recorded a win in three of his last four appearances with the Orioles as road favorites.
  • Zach Eflin has recorded five or more strikeouts in five of his last six appearances against AL West opponents.
  • Gunnar Henderson has scored at least one run in seven of the Orioles’ last eight games against the Angels.
  • Ryan Mountcastle has recorded at least one Single in nine of his last 10 appearances at Angel Stadium of Anaheim.
  • Cedric Mullins has recorded at least one hit in each of his last 12 appearances in day games against teams that held a losing record.
  • Gary Sanchez has recorded at least one RBI in each of his last four appearances with his team as a favorite against AL opponents.

Los Angeles Angels Recap

The Los Angeles Angels will be out to add on to their win over the Orioles from Saturday’s matchup to improve their record to 16-22 on the year. After this series, the Angels will head on the road for an interleague series against the San Diego Padres.

Angels Looking To Win Rubber Match

Logan O’Hoppe has 31 hits, including 9 home runs and 17 RBIs, while Nolan Schanuel has 31 hits with 6 doubles, a triple, 2 home runs, and 9 RBIs. Luis Rengifo has 5 doubles with his 25 hits, and Taylor Ward also has 25 hits as well, while Mike Trout’s added 9 home runs and 18 RBIs so far this season. Jorge Soler also has 8 doubles, 6 home runs, and 16 RBIs, but also has the unfortunate distinction of leading the Angels with 41 strikeouts so far this season. Kyren Paris has also chipped in 21 hits with a triple, 6 home runs, and 11 RBIs in addition to 5 stolen bases.

Why the Los Angeles Angels will win

  • The Orioles have lost seven of their last eight games as road favorites.
  • The Angels have won four of their last six games as underdogs against AL East opponents.
  • The Orioles have failed to cover the run line in seven of their last eight games as road favorites.
  • The Angels have covered the run line in five of their last six home games against the Orioles following a home win.

Los Angeles Angels Player Prop Facts

  • Taylor Ward has recorded at least one RBI in six of the Angels’ last seven games against AL East opponents.
  • Yoan Moncada has scored a run in nine of his last 10 home appearances against opponents that held a losing record.
  • Tyler Anderson has recorded five or more strikeouts in each of his last five appearances with the Angels as underdogs.
  • Mike Trout has hit a home run in each of his last two home appearances against the Orioles.
  • Tim Anderson has recorded at least one Single in 10 of his last 11 appearances at Angel Stadium of Anaheim against opponents that held a losing record.
  • Mike Trout has recorded at least one hit in each of his last 13 home appearances against AL East opponents that held a losing record.

Total Runs Facts

  • Each of the Orioles’ last seven day games as favorites have gone OVER the total runs line.

Angels vs Orioles Prediction

I’m on the Angels here. It’s just really hard to back Baltimore given their issues against left-handed pitching so far this season, and Anderson has actually been a fairly reliable option for the Halos up to this point. The Orioles continue to have issues across the board, and I’m starting to wonder if the issues are going to be fixable before it’s too late. The Angels aren’t a team I rush to back consistently, but I think they’re good enough here to snag the win at home to win the series. Give me the Angels.

Chris Ruffolo's Free Pick: LA Angels +120

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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