Arizona Diamondbacks vs Colorado Rockies Prediction 5/22/26 MLB Picks Today

The Colorado Rockies and the Arizona Diamondbacks meet Friday in MLB action from Chase Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Rockies vs. Arizona Diamondbacks prediction.

Starting Pitching Matchup

The Colorado Rockies will send out Tomoyuki Sugano for the start here and Sugano is 4-3 with a 4.02 ERA and 25 strikeouts this season. This will be Sugano’s second career start against Arizona. Michael Soroka will start here for the Diamondbacks and is 6-2 with a 3.49 ERA and 55 strikeouts this season. In his career, Soroka is 1-1 with a 3.86 ERA and 17 strikeouts against the Rockies.

Colorado Rockies Recap

The Colorado Rockies come into this game looking to bounce back from a 2-1 loss at the hands of the Diamondbacks in Thursday’s series opener to sit at 19-22 this season. After this series, the Rockies will head on the road for a series against the Los Angeles Dodgers.

Rockies Lose 3 In A Row

TJ Rumfield has 50 hits with 8 doubles, a triple, 6 home runs and 25 RBIs while Ezequiel Tovar has 34 hits with 11 doubles, a home run and 13 RBIs. Hunter Goodman’s added 41 hits with 8 doubles, 11 home runs and 19 RBIs and Jordan Beck has 10 RBIs as well on the year. Troy Johnston has 48 hits with 13 doubles, 2 home runs and 22 RBIs. Willi Castro also has 33 hits with 8 doubles, 2 home runs and 16 RBIs.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their series opening win over Colorado last time out to sit at 26-23 this season. After this series, the Diamondbacks will head on the road for a series against the San Francisco Giants.

Diamondbacks Win 5 In A Row

Corbin Carroll has 46 hits including 11 doubles, 6 triples, 7 home runs and 26 RBIs while Alek Thomas has logged 9 doubles with 2 home runs and 10 RBIs as well this season. Ketel Marte has 44 hits with 7 doubles, 7 home runs and 22 RBIs and Geraldo Perdomo has 35 hits, with 8 doubles, 3 triples, 2 home runs and 15 RBIs as well this season. Nolan Arenado also has 42 hits with 9 doubles, 7 home runs and 25 RBIs and Jose Fernandez has 36 hits with 3 home runs and 14 RBIs this season. Ildemaro Vargas also has 55 hits with 8 doubles, 2 triples, 7 home runs and 32 RBIs.

Colorado Rockies @ Arizona Diamondbacks Betting Trends: May 22, 2026

• Probable Starting Pitcher: Michael Soroka      Record this season: 6-2      ERA: 3.49
• Home Record: 3-1
• Last 5 against Rockies: 1-2

Why the Arizona Diamondbacks will win

• The Rockies have lost each of their last 10 road games against NL West opponents.
• The Diamondbacks have won each of their last six home games.
• The Rockies have failed to cover the run line in seven of their last eight games against NL West opponents following a road loss.
• The Diamondbacks have covered the run line in five of their last six home games.
• The Rockies have trailed after 5 innings in seven of their last eight games at Chase Field.
• The Rockies have lost the first inning in four of their last five games at Chase Field.
• The Rockies have trailed after 3 innings in five of their last six road games.

• Probable Starting Pitcher: Tomoyuki Sugano      Record this season: 4-3      ERA: 4.02
• Road Record: 1-1
• Last 5 against Diamondbacks: 1-0

Why the Colorado Rockies will win

• The Diamondbacks have failed to cover the run line in each of their last seven night games against the Rockies following a home win.
• The underdogs have covered the run line in each of the Rockies’ last four games.

Total Runs Facts

• Each of the Rockies’ last four night games against NL West opponents have gone UNDER the total runs line.
• Five of the Diamondbacks’ last six night games against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the last 10 night games between the Rockies and Diamondbacks.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Rockies’ last six games at Chase Field.

Arizona Diamondbacks Player Prop Facts

• Corbin Carroll has hit at least one home run in two of his last three appearances against the Rockies after playing the previous day.
• Michael Soroka has recorded a win in four of his last five appearances with the Diamondbacks as favorites.
• Michael Soroka has recorded six or more strikeouts in five of his last six appearances with his team as a favorite against NL West opponents.
• Gabriel Moreno has recorded at least one hit in each of his last eight appearances against the Rockies.
• Michael Soroka ranks T3rd in the league for Wins (6) this season.

Colorado Rockies Player Prop Facts

• Jake McCarthy has recorded a hit in each of his last eight road appearances after playing the previous day.
• Brenton Doyle has hit a home run in each of his last two road appearances against the Diamondbacks.
• Mickey Moniak ranks 3rd amongst qualified players for Slugging Percentage (.607) this season.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (14).
• The Diamondbacks rank 30th in the league for strikeouts this season (357).
• The Rockies rank 30th in the league for opponent batting average this season (.275).
• The Rockies rank 30th in the league for hits allowed this season (483).

Colorado Rockies vs. Arizona Diamondbacks Prediction

I’m on the Diamondbacks here. The Rockies’ struggles on the road have been well documented over the years and I don’t really expect that to change here against Soroka who just stifled the Rockies in his last start against them. Sugano won his last start against Arizona in fairness, but I trust Arizona’s bats to replicate their success here more than I do Colorado’s. Give me the Diamondbacks.