Cleveland Guardians vs NY Yankees Prediction 6/10/26 MLB Picks Today

The New York Yankees and the Cleveland Guardians meet Wednesday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Yankees vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The New York Yankees will send out Carlos Rodon for the start and Rodon is 1-2 with a 2.88 ERA and 27 strikeouts this season. In his last five starts against the Guardians, Rodon is 3-0 with a 2.18 ERA and 40 strikeouts. Parker Messick will start for the Guardians and is 6-2 with a 2.40 ERA and 78 strikeouts this season. This will be Messick’s first career start against the Yankees.

New York Yankees Recap

The New York Yankees come into this game looking to add on to their 3-2 win over the Guardians from Tuesday to sit at 40-26 this season. After this series, the Yankees will head on the road for a series against the Toronto Blue Jays.

Yankees Win 3 Straight

Entering Tuesday, Ben Rice has 66 hits with 15 doubles, 18 home runs and 45 RBIs and Aaron Judge has 53 hits with 10 doubles, 17 home runs and 38 RBIs. Cody Bellinger also has 64 hits with 13 doubles, 3 triples, 9 home runs and 43 RBIs. Jazz Chisholm Jr. also has 52 hits with 10 doubles, 8 home runs and 25 RBIs as well on the year.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to bounce back from their loss at the hands of the Yankees on Tuesday to sit at 37-32 this season. After this series, the Guardians will take on the Tigers at home.

Guardians Lose 5 Of Last 6

Going into Tuesday, Chase DeLauter has 59 hits with 11 doubles, 7 home runs and 33 RBIs while Steven Kwan has 47 hits with 8 doubles, a home run and 12 RBIs and Jose Ramirez has 60 hits with 17 doubles, 10 home runs and 33 RBIs this season. Brayan Rocchio has also added 60 hits with 9 doubles, 5 home runs and 30 RBIs this season while Angel Martinez has 49 hits with 10 doubles, 10 homers and 31 RBIs and Rhys Hoskins has added 27 hits with 10 doubles, 6 home runs and 24 RBIs. Daniel Schneemann has 39 hits with 9 doubles, 4 home runs and 20 RBIs this season.

New York Yankees @ Cleveland Guardians Betting Trends: June 10, 2026

• Probable Starting Pitcher: Parker Messick      Record this season: 6-2      ERA: 2.40
• Home Record: 3-0
• Last 5 against Yankees: –

Why the Cleveland Guardians will win

• The Guardians have won each of their last seven Wednesday games against AL East opponents.
• The Yankees have lost six of their last seven day games against AL Central opponents following a road win.
• The Guardians have covered the run line each of their last eight Wednesday games against American League opponents that held a winning record.
• The Yankees have failed to cover the run line in seven of their last eight day games against AL Central opponents following a road win.
• The Guardians have led after 3 innings in six of their last seven games as home favorites against American League opponents.
• The Guardians have led after 5 innings in four of their last five home day games.

• Probable Starting Pitcher: Carlos Rodon      Record this season: 1-2      ERA: 2.88
• Road Record: 1-1
• Last 5 against Guardians: 3-0

Why the New York Yankees will win

• The Yankees have won each of their last 10 Wednesday road games against AL Central opponents.
• The Guardians have lost each of their last four games as favorites.
• The Guardians have failed to cover the run line in each of their last eight games as favorites.
• The underdogs have covered the run line in each of the Guardians’ last eight games at Progressive Field.
• The Yankees have led after 5 innings in six of their last seven road games against AL Central opponents.
• The Yankees have won the first inning in three of their last four games at Progressive Field.
• The Yankees have led after 3 innings in five of their last six day games against AL Central opponents.

Total Runs Facts

• Seven of the Yankees’ last eight games as underdogs against American League opponents have gone OVER the total runs line.
• Eight of the Guardians’ last 10 games as home favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Guardians’ last five games as favorites.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Yankees’ last seven day games.

Cleveland Guardians Player Prop Facts

• Rhys Hoskins has hit a home run in three of his last four Wednesday appearances against AL teams that held a winning record.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last nine games against the Yankees.
• Jose Ramirez ranks T1st in the league in Steals (24) this season.

New York Yankees Player Prop Facts

• Carlos Rodon has recorded a win in five of his last six road appearances against AL opponents.
• Carlos Rodon has recorded six or more strikeouts in each of his last nine appearances against the Guardians.
• Paul Goldschmidt has recorded at least one hit in each of his last 11 road appearances against AL opponents.
• Giancarlo Stanton has hit a home run in six of his last seven road appearances against AL Central opponents that held a winning record.
• Ben Rice ranks 2nd amongst qualified players for Slugging Percentage (.626) this season.

Matchup/League Facts

• The Guardians rank 2nd in the league for strikeouts this season (631).
• The Guardians rank 28th in the league for slugging percentage this season (.371).
• The Yankees rank 1st in the league for home runs this season (97).
• The Yankees rank 1st in the league for home runs allowed this season (56).

New York Yankees vs. Cleveland Guardians Prediction

I’m on the Yankees here. I just feel like I can trust this Yankee lineup a lot more against left-handed pitching as even without Aaron Judge they’ve been one of the more potent lineups in baseball in that regard. The Guardians are just hit or miss right now and I think that the Yankees complete the sweep here. Give me New York.