Astros vs Angels Prediction 6/22/25 MLB Picks Today

The Houston Astros are visiting the Los Angeles Angels on Sunday, June 22^nd at the Angel Stadium in the second game of this series, with both teams being tied 1-1 wins. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Astros vs Angels Prediction. We will examine:

The Los Angeles Angels recent form and player performance

The Houston Astros recent form and player performance

Recent betting trends and streaks involving the Los Angeles Angels

Recent betting trends and streaks involving the Houston Astros

Recent betting trends in games played between the Houston Astros vs Los Angeles Angels

A summary that ties it all together and produces a favorable betting outcome for the Houston Astros vs Los Angeles Angels game

Los Angeles Angels Preview

The Los Angeles Angels have a 37-39 record this season and are sitting on the 4^th place of the AL West. The Angels have a 16-17 home record and 39-36 in over/under They are coming off a 9-1 home victory over the Astros, which snapped their previous two-game losing streak. Under is 5-1 in their last 6 games and are playing the Red Sox and the Nationals next.

The Angels have a .225 batting average this season, .288 OBP and .401 Slugging percentage. LA’s pitching staff has a 4.58 ERA and 1.46 WHIP. Nolan Schanuel leads the Angels with 74 hits and he is the team’s best hitter with a .277 batting average. Taylor Ward leads the team with 52 RBI and a team-high 19 home runs.

Kyle Hendricks (R) will take the mound for the Angels, and he has a 5-6 record, 4.79 ERA and 1.29 WHIP. He has been better at home with a 4.04 ERA across six home starts, and he is coming off a shutout start in 6 innings pitched against the Yankees. In his previous start against the Astros this season, he gave up 5 runs across 4 innings of work, as the Angels lost 3-7.

Houston Astros Preview

The Houston Astros have a 44-33 record this season and are sitting on the first place of the AL West. The Astros have a 17-20 road record and 32-42 in over/under. They are coming off a 1-9 road defeat by the Angels, but still are are 8-3 in their last 11 games. Over is 4-1 in their last 5 games, and they are playing the Cubs and the Phillies next.

The Astros have a .256 batting average this season, .322 OBP and .399 slugging percentage. Houston’s pitching staff has a 3.48 ERA and 1.15 WHIP. Jeremy Pena leads the Astros with 97 hits and he is the team’s best hitter, with a .324 batting average. Isaac Paredes leads the team in RBI with 45, adding a team-high 16 home runs.

Ryan Gusto (R) is the projected starter for the Astros, and he has a 4-3 record, 4.31 ERA and 1.53 WHIP. He has been better on the road, with a 2.40 ERA across 6 road games, and he is coming off a quality start against the Athletics, where he gave up one runs across 5 innings of work. In his previous start against the Angels this season, he gave up 3 runs in 4 innings of work, as the Astros lost 1-4.

Why the Los Angeles Angels will win

• The Angels have won five of their last six games as underdogs against AL West opponents following a win.
• The Astros have lost eight of their last 16 games as road favorites against American League opponents.
• The Angels have covered the run line in each of their last eight games as underdogs against AL West opponents.
• The Astros have failed to cover the run line each of their last three games against teams that held a losing record.
• The Astros have trailed after 5 innings in three of their last four road day games.

Why the Houston Astros will win

• The Angels have lost each of their last 11 games against the Astros following a home win.
• The Astros have won each of their last 11 games against the Angels following a loss.
• The Angels have failed to cover the run line in each of their last four games against the Astros following a win.
• The Astros have covered the run line in six of their last seven day games against the Angels following a loss.
• The Angels have lost the first inning in four of their last five games as underdogs against AL West opponents.
• The Angels have trailed after 3 innings in 13 of their last 14 day games against AL West opponents.
• The Angels have trailed after 5 innings in eight of their last nine day games against AL West opponents.

Total Runs Facts

• Each of the Angels’ last five games as underdogs have gone UNDER the total runs line.
• Four of the Astros’ last five road games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Angels’ last six day games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last four day games.

Matchup/League Facts

• The Angels rank 30th in the league for on-base percentage this season (.288).
• The Angels rank 29th in the league for doubles this season (99).
• The Astros rank 1st in the league for strikeouts this season (755).
• The Astros rank 2nd in the league for opponent batting average this season (.219).

Astros vs Angels Prediction

The Astros are 9-3 in their last 12 overall meetings against the Angels, and are 4-1 in their last 5 visits in Los Angeles. Over is 6-2 in their last 8 meetings.

In this Astros vs Angels Prediction, the Astros are coming as -135 road favorites. The Astros are rightfully favored, as they have a better overall record, but both teams have similar home/away splits. The Angels have the 4^th-worst bullpen in the league and I don’t trust any of those pitchers, as they have a combined 9.10 ERA, and in their previous start against the other team this season, they got hit, with 3 and 5 earned runs respectively. In a hitter-friendly park, I expect a high-scoring game, so take the over 9 runs in this one.