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Astros vs Blue Jays Prediction 4/22/25 MLB Picks Today

Toronto Blue Jays (12-11) vs. Houston Astros (11-11)
April 22, 2025 8:10 pm EDT
The Line: Houston Astros -112 / Toronto Blue Jays -108; Over/Under: 8
(Get latest betting odds)

In this article, we will formulate an Astros vs Blue Jays prediction for this MLB game on Tuesday, April 22, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup.

Toronto Blue Jays Betting Preview

The Toronto Blue Jays (12-11, 4-6 Away) are on a three-game losing skid after losing Game 1 of the series against the Astros. Prior to this series in Houston, Toronto lost to the Mariners and beat the Braves. For the second time this season, the Blue Jays failed to score a single run as they lost 7-0 to the Astros. Kevin Gausman took the loss after allowing four runs on six hits with six strikeouts and three walks over 6.0 innings of work.

This season, the Blue Jays average 3.91 runs per game (22nd in the MLB) on a .259/.333/.368 slash line. Regarding pitching, the Blue Jays’ staff has a 3.58 ERA (8th) and 1.10 WHIP (4th). Bo Bichette leads the Blue Jays with a .310 batting average, no home runs, and 13 RBI this season.

The projected starting pitcher for the Blue Jays is Chris Bassitt, who is 2-0 in four starts this season, with a 0.77 ERA and 1.07 WHIP in 23.1 innings.

Houston Astros Betting Preview

The Houston Astros (11-11, 7-6 Home) have been inconsistent so far this season, but they did win three of the previous four games. After winning the series over the Padres, the Astros defeated the Blue Jays 7-0 in Game 1 of the current series. It was the second time this season the Astros kept the opponents off the scoreboard. Jose Altuve and Brendan Rodgers led the team with two RBI apiece, while Hunter Brown got the win after allowing no runs on two hits with nine strikeouts and one walk in 7.0 innings.

This year, the Astros average 3.67 runs per game (24th in the MLB) on a .222/.299/.331 triple-slash. When it comes to pitching, the Astros’ staff has a 3.63 ERA (10th) and 1.15 WHIP (7th). Isaac Paredes leads the Astros with a .232 batting average, three home runs, and 12 RBI this season.

Ronel Blanco will take the mound for the Astros on Tuesday. The 31-year-old right-hander has a 1-2 record in four starts this year with a 6.48 ERA and 1.68 WHIP in 16.2 innings.

Total Runs Facts

  • Each of the Blue Jays’ last five night games against American League opponents have gone UNDER the total runs line.
  • Each of the Astros’ last four night games after playing the previous day have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the Astros’ last 14 night games.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Blue Jays’ last six games at Daikin Park.

Matchup/League Facts

  • The Astros rank 27th in the league for slugging percentage this season (.336).
  • The Astros rank 5th in the league for opponent batting average this season (.212).
  • The Blue Jays rank T3rd in the league for strikeouts this season (222).
  • The Blue Jays rank T27th in the league for home runs allowed this season (31).

Astros vs Blue Jays Prediction

The Astros won six of the previous ten H2H encounters, including five of the last six. Chris Bassitt has been phenomenal so far this season, as he has not allowed more than a run in any of his four starts. However, Bassitt allowed a .256 BA in 121 at-bats against the Astros, while he posted a 7.71 ERA in two starts (both losses) against Houston last season. Ronel Blamco, on the other hand, was great against Toronto last year, as he registered a 1.23 ERA in two starts (14.2 innings) and even had a complete game shutout. Blanco is not playing well early in this season, though, so I believe both pitchers will allow multiple runs in the opening five innings. Back the Over.

Oliver Zivic's Free Pick: Over 7.5

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Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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