Astros vs Cardinals Prediction 4/19/26 MLB Picks Today

In this article we will formulate an Astros vs Cardinals prediction for this MLB game on Sunday, April 19th at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 8-14 this year after they lost the first two games in this series by scores of 4-9 and 5-7. In game two, Houston cut the deficit to 2-1 in the first inning, but they didn’t score again until the eighth in the loss. The Astros recorded four hits and they committed two errors in the game, while they were led by Whitcomb, who went 1-4 with one home run and three RBIs. McCullers Jr allowed four hits and four earned runs over 5.0 innings for the loss, while Gordon allowed three earned runs in relief. Prior to this series, Houston won two out of three against the Rockies, but lost all four against the Mariners before that. 

This season, Houston has a 6.19 ERA with a 1.65 WHIP and a .266 opponent batting average, while they have scored 116 runs with a .257 batting average and a .352 on base percentage. Yordan Alvarez has led the Astros with nine home runs and 20 RBIs, while Christian Walker has added four home runs and 16 RBIs. The projected starting pitcher for Houston is Mike Burrows, who is 1-3 with a 6.55 ERA and a 1.82 WHIP over 22.0 innings pitched this year. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 12-8 this season after they won game two by a score of 7-5 on Saturday night. St. Louis scored two runs in the first inning and they added two more in the third + one more in the sixth to pull away for the win. The Cardinals recorded nine hits in the game and they were led by Gorman and Winn, who both had two RBIs. Pallante allowed three hits and one earned run over 5.0 innings for the win, while O’Brien picked up the save. Prior to this series, St. Louis won two out of three against the Guardians, but lost two out of three against the Red Sox before that. 

This season, St. Louis has a 4.90 ERA with a 1.43 WHIP and a .256 opponent batting average, while they have scored 96 runs with a .234 batting average and a .330 on base percentage. Jordan Walker has led the Cardinals with eight home runs and 16 RBIs, while Alec Burleson has added three home runs and 15 RBIs. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 0-1 with a 4.29 ERA and a 1.57 WHIP over 21.0 innings pitched this season. 

Why the Houston Astros will win

• The Astros have won each of their last five day games against National League opponents that held a winning record.
• The Cardinals have lost five of their last six games against AL West opponents following a road win.
• The Cardinals have failed to cover the run line each of their last four day games against American League opponents that held a losing record.
• The Astros have covered the run line in five of their last six day games against National League opponents following a home loss.
• The Cardinals have lost the first inning in each of their last three day games against American League opponents.
• The Astros have led after 3 innings in four of their last five day games against NL Central opponents that held a winning record.
• The Astros have led after 5 innings in each of their last five day games against NL Central opponents that held a winning record.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last four games as road underdogs.
• The Astros have lost eight of their last 10 games as favorites.
• The Astros have failed to cover the run line in nine of their last 10 games as favorites.
• The Cardinals have covered the run line in each of their last four games.
• The Astros have lost the first inning in eight of their last 10 games.
• The Astros have trailed after 3 innings in seven of their last eight games against opponents that held a winning record.
• The Astros have trailed after 5 innings in seven of their last eight games against opponents that held a winning record.

Total Runs Facts

• Each of the Cardinals’ last six games as underdogs have gone OVER the total runs line.
• Six of the last seven games between the Cardinals and Astros at Daikin Park have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last 10 games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last six games.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit a home run in each of his last three appearances against the Cardinals.
• Yordan Alvarez has recorded at least one hit in each of the Astros’ last 11 home games.

St. Louis Cardinals Player Prop Facts

• Masyn Winn has hit a home run in each of his last two appearances against the Astros after playing the previous day.
• Alec Burleson has recorded at least one hit in each of his last 11 road appearances against AL opponents that held a losing record.

Astros vs Cardinals Prediction 

Houston comes into this matchup on a three game losing streak and they have allowed 16 runs in the first two games of this series. The Astros are 7-5 at home this year, while the Cardinals are 5-3 on the road. St. Louis has won four games in a row and they have scored 5+ runs in all four wins. The Cardinals are starting Liberatore, who has allowed eight earned runs and 15 hits over his last 10.0 innings, while Burrows has allowed 6, 3, 2, and 5 earned runs in his first four starts. I think we are going to see plenty of scoring in this one, but I like the Cardinals, as this Houston pitching staff continues to be a disaster.