Astros vs Cubs Prediction 6/28/25 MLB Picks Today

The Chicago Cubs and Houston Astros meet Saturday in MLB action at Daikin Park. Here’s an Astros vs Cubs Prediction. This article will include an Astros vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 48-34 on the year and play the Guardians, Cardinals, and Twins next. The Chicago Cubs are batting .255 on the season, have a .325 OBP, and a .444 slugging percentage. The Chicago Cubs pitching staff has a 3.89 ERA and a 1.26 WHIP. Nico Hoerner leads the Chicago Cubs with 88 hits and 34 RBI, while Kyle Tucker and Pete Crow-Armstrong have combined for 171 hits and 110 RBI.

Colin Rea gets the ball for the Chicago Cubs, and he is 4-3 with a 4.42 ERA and 54 strikeouts this season. Rea is 1-1 with a 4.66 ERA and 9 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 49-33 on the year and play the Rockies, Dodgers, and Guardians next. The Houston Astros are batting .256 on the season, have a .322 OBP, and a .400 slugging percentage. The Houston Astros’ pitching staff has a 3.41 ERA and a 1.14 WHIP. Jeremy Pena leads the Houston Astros with 102 hits and 40 RBI, while Jake Meyers and Jose Altuve have combined for 160 hits and 54 RBI.

Lance McCullers Jr. gets the ball for the Houston Astros, and he is 1-2 with a 4.91 ERA and 39 strikeouts this season. This will be McCullers’ first career game against the Chicago Cubs.

Why the Houston Astros will win

• The Astros have won each of their last nine games at Daikin Park.
• The Cubs have lost eight of their last nine road games against AL West opponents that held a winning record.
• The Cubs have failed to cover the run line in each of their last four games as underdogs against American League opponents.
• The home team has covered the run line in each of the last four games between the Cubs and Astros.
• The Astros have led after 3 innings in five of their last six home night games.
• The Cubs have trailed after 5 innings in each of their last seven games as underdogs.

Why the Chicago Cubs will win

• The Cubs have won seven of their last eight games as underdogs following a road loss.
• The Astros have lost four of their last five games as favorites against NL Central opponents following a home win.
• The Cubs have covered the run line in each of their last eight games as underdogs following a road loss.
• The Astros have failed to cover the run line in seven of their last eight games as favorites against National League opponents following a home win.
• The Cubs have won the first inning in three of their last four night games against the Astros.
• The Cubs have led after 3 innings in each of their last six Saturday games against opponents that held a winning record.
• The Cubs have led after 5 innings in each of their last six Saturday games against opponents that held a winning record.

Houston Astros Player Prop Facts

• Lance McCullers Jr. has recorded six or more strikeouts in each of his last four appearances.
• Yordan Alvarez has recorded a Double in each of his last five Saturday appearances at Daikin Park.
• Yainer Diaz has hit a home run in each of the Astros’ last two home games against NL Central opponents.
• Yainer Diaz has recorded at least one hit in each of the Astros’ last 10 home games against NL Central opponents.
• Jake Meyers ranks 10th amongst qualified players for Batting Average (.307) this season.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has hit at least one home run in two of his last three appearances with the Cubs as underdogs against the Astros.
• Justin Turner has recorded at least one hit in each of his last 14 appearances in night games against AL teams that held a winning record.
• Pete Crow-Armstrong ranks 3rd in the league in Steals (24) this season.

Astros vs Cubs Prediction

I’m not excited to get behind McCullers and his up-and-down performances, especially when he hasn’t pitched in two weeks due to a foot injury. However, Rea has been hittable this season, as he’s allowed 27 hits and 13 runs in his last 21 innings, and he has a .291 allowed batting average in 27.2 road innings. The Astros are on fire right now and their lineup should be excited about this matchup. The Astros are a team to watch if they can stay in this form. Give me the home team on Saturday night.