Astros vs Giants Prediction 4/2/25 MLB Picks Today

The San Francisco Giants and Houston Astros meet on Wednesday in MLB action at Daikin Park. Here’s an Astros vs Giants Prediction. This article will include an Astros vs Giants Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 3-1 on the year and play the Mariners, Reds, and Yankees next. The San Francisco Giants are batting .206 on the season, have a .269 OBP, and a .382 slugging percentage. The San Francisco Giants’ pitching staff has a 2.66 ERA and a 0.93 WHIP. Heliot Ramos leads the San Francisco Giants with 6 hits and 5 RBI, while Jung Hoo Lee and Mike Yastrzemski have combined for 10 hits and 2 RBI.

Landen Roupp gets the ball for the San Francisco Giants, and he was 1-2 with a 3.58 ERA and 47 strikeouts last season. This will be Roupp’s first career game against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 2-3 on the year and play the Twins, Mariners, and Angels next. The Houston Astros are batting .171 on the season, have a .261 OBP, and a .226 slugging percentage. The Houston Astros’ pitching staff has a 2.80 ERA and a 1.04 WHIP. Jose Altuve leads the Houston Astros with 7 hits and 1 RBI, while Isaac Paredes and Christian Walker have combined for 6 hits and 2 RBI.

Framber Valdez gets the ball for the Houston Astros, and he is 1-0 with a 0.00 ERA and 4 strikeouts this season. Valdez is 1-2 with a 5.40 ERA and 15 strikeouts in his career against the San Francisco Giants.

Why the Houston Astros will win

• The Astros have won five of their last six day games against National League opponents following a loss.
• The Giants have lost four of their last five day games against AL West opponents following a win.
• The Astros have covered the run line in each of their last four day games against NL West opponents following a loss.
• The Giants have failed to cover the run line in six of their last eight day games against the Astros following a win.
• The Giants have trailed after 3 innings in nine of their last 12 games at Daikin Park against AL West opponents that held a losing record.
• The Astros have led after 5 innings in 10 of their last 12 day games at Daikin Park against National League opponents.

Why the San Francisco Giants will win

• The Giants have won each of their last four games as underdogs against American League opponents.
• The Astros have lost seven of their last eight home games against teams that held a winning record.
• The Astros have failed to cover the run line each of their last eight home games against teams that held a winning record.
• The road team has covered the run line in each of the Giants’ last eight games.
• The Giants have led after 5 innings in seven of their last eight games against American League opponents.
• The Giants have won the first inning in three of their last four games as underdogs against AL West opponents.
• The Giants have led after 3 innings in seven of their last eight games as underdogs.

Astros vs Giants Prediction

Roupp has yet to make his season debut, and he has just 50 MLB innings under his belt overall, so he’s not a starter I’m thrilled to get behind. The jury is still out on Roupp. Valdez looked great in his season debut, and it’s only a matter of time before the Astros wake up offensively.

The Astros have scored no more than three runs in their first five games, and with this lineup, that’s not going to be the norm. I’m banking on a breakthrough offensively, as the Astros are due, and they’re going up against a pitcher who hasn’t been able to get the jitters out of the way yet. Give me the Astros on Wednesday afternoon.