Astros vs Mariners Prediction 4/10/26 MLB Picks Today

In this article, we will formulate an Astros vs Mariners Prediction for this MLB matchup on Friday, April 10^th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 4-9 record this season and are sitting in the fifth place of the AL West. They have a 3-4 home record and are coming off a 0-3 road loss against the Rangers. Their previous three games were a 2-3 and a 1-2 road loss to the Rangers, and a 7-8 road loss to the Angels.

The Mariners have a .184 batting average this season, .280 OBP and .301 Slugging percentage. Seattle’s pitching staff has a 2.62 ERA and 0.95 WHIP. Brendan Donovan is the team’s best hitter with a .316 batting average. Cole Young leads the team in RBI with 8, and Luke Raley adds a team-high 3 home runs.

Emerson Hancock (R) is the projected starting pitcher for the Mariners, and he has a 1-1 record, 0.71 ERA and 0.55 WHIP.

Houston Astros Preview

The Houston Astros have a 6-7 record this season and are sitting in the second place of the AL West. They have a 1-5 away record and are coming off a 1-9 road loss against the Rockies. Their previous three games were a 1-5 and a 7-9 road loss to the Rockies, and a 10-12 road loss to the Athletics.

The Astros have a .271 batting average this season, .371 OBP and .453 Slugging percentage. Houston’s pitching staff has a 6.05 ERA and 1.63 WHIP. Christian Walker is the team’s best hitter with a .340 batting average, also leading the team in RBI with 13. Yordan Alvarez adds a team-high 4 home runs.

Tatsuya Imai (R) is the projected starting pitcher for the Astros, and he has a 1-0 record, 4.32 ERA and 1.56 WHIP.

Houston Astros @ Seattle Mariners Betting Trends: April 10, 2026

• Probable Starting Pitcher: Emerson Hancock      Record this season: 1-1      ERA: 0.71
• Home Record: 1-0
• Last 5 against Astros: 1-0

Why the Seattle Mariners will win

• The Mariners have won each of their last 10 home games against teams that held a losing record.
• The Astros have lost each of their last four games.
• The Astros have failed to cover the run line in 13 of their last 15 night games against AL West opponents that held a losing record.
• The home team has covered the run line in each of the Astros’ last four games.
• The Mariners have led after 3 innings in each of their last five games against the Astros.
• The Mariners have led after 5 innings in each of their last five night games against the Astros.

• Probable Starting Pitcher: Tatsuya Imai      Record this season: 1-0      ERA: 4.32
• Road Record: 1-0
• Last 5 against Mariners: –

Why the Houston Astros will win

• The underdogs have won each of the Astros’ last seven games.
• The Mariners have lost each of their last four games as favorites.
• The Astros have covered the run line in each of their last 10 games as underdogs following a road loss.
• The Mariners have failed to cover the run line in each of their last four games as favorites.
• The Astros have led after 3 innings in three of their last four night games against American League opponents that held a losing record.
• The Mariners have trailed after 5 innings in each of their last four games as favorites.
• The Astros have won the first inning in each of their last three games as underdogs.

Total Runs Facts

• Each of the Astros’ last eight games against American League opponents have gone OVER the total runs line.
• Each of the Mariners’ last six night games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last 11 games at T-Mobile Park.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last seven night games between the Astros and Mariners at T-Mobile Park.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit a home run in each of the Mariners’ last two games against the Astros.
• Randy Arozarena has recorded at least one hit in each of the Mariners’ last six games against opponents that held a losing record.

Houston Astros Player Prop Facts

• Christian Walker has hit at least one home run in five of his last six road appearances against AL West opponents.
• Christian Walker has recorded at least one hit in 26 of his last 27 road appearances against opponents that held a losing record.
• Yordan Alvarez ranks 1st amongst qualified players for On Base Percentage (.500) this season.

Matchup/League Facts

• The Mariners rank 30th in the league for batting average this season (.184).
• The Mariners rank 30th in the league for slugging percentage this season (.301).
• The Astros rank 1st in the league for runs scored this season (79).
• The Astros rank 1st in the league for hits this season (122).

Astros vs Mariners Prediction

The Mariners are 5-1 in their last 6 meetings against the Astros and the over is 4-1 in their last 5 meetings.

In this Astros vs Mariners Prediction, the Mariners are coming as -140 home favorites. Both teams have been struggling early this season as they have lost their last five and four games respectively. The Mariners have the pitching edge in this one, as Hancock goes up against Tatsuya Imai, with Hancock having just one earned run in two starts. Imai is coming off a shutout start and the Astros have scored just 2 total runs in their last two games. The Mariners have the third-best bullpen in baseball and are 7-2 to the under in their last 9 games, barely averaging 3+ runs this season, so this sets up for a low-scoring affair. Take the under 7.5 in this one.