Astros vs Padres Prediction 4/19/25 MLB Picks Today

The San Diego Padres and the Houston Astros meet Saturday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Astros vs Padres Prediction.

Starting Pitching Matchup

The San Diego Padres will start Michael King in this one and King is 3-0 with a 2.42 ERA and 24 strikeouts this season. In his career, King is 1-0 with a 2.25 ERA and 11 strikeouts against Houston. The Houston Astros will send out Hayden Wesneski for the start here and Wesneski is 1-1 with a 4.00 ERA and 21 strikeouts this season. In his career, Wesneski is 1-1 with a 3.27 ERA and 6 strikeouts against the Padres.

San Diego Padres Recap

The San Diego Padres come into this game looking to bounce back from a 6-4 loss at the hands of the Astros in Friday’s series opener to fall to 15-5 on the year. After this series, the Padres will head on the road for an interleague series against the Detroit Tigers.

Padres Looking To Rebound

Manny Machado has 23 hits including a team-high 8 doubles and 6 stolen bases while Fernando Tatis Jr. has 24 hits with a team-high 6 home runs and 14 RBIs along with 6 stolen bases of his own this season. Luis Arraez has added 22 hits with 3 doubles while Jackson Merrill’s added 14 hits with 3 home runs and 10 RBIs as well. Xander Bogaerts also has 6 doubles and 4 stolen bases as well this season.

Why the San Diego Padres will win

• The Astros have lost each of their last nine games following a win.
• The Padres have won each of their last seven games against American League opponents following a loss.
• The Astros have failed to cover the run line in each of their last seven games against National League opponents following a win.
• The Padres have covered the run line in each of their last six games after playing the previous day.

San Diego Padres Player Prop Facts

• Xander Bogaerts has recorded at least one Double in three of the Padres’ last four road games against AL West opponents.
• Fernando Tatis Jr. has hit at least one home run in three of the Padres’ last four games as favorites.
• Manny Machado has recorded at least one RBI in each of the Padres’ last seven games as favorites against the Astros.
• Manny Machado has scored at least one run in seven of the Padres’ last eight games as favorites.
• Luis Arraez has recorded at least one Single in each of his last 11 Saturday appearances against AL teams that held a losing record.
• Manny Machado has recorded two or more hits in each of his last eight appearances with his team as a favorite against the Astros.
• Michael King ranks T1st in the league for Wins (3) this season.

Houston Astros Recap

The Houston Astros will be out to keep the ball rolling after their series opening win over the Padres on Friday to improve to 9-10 on the year. After this series, the Astros will welcome the Toronto Blue Jays to town.

Astros Start Series On The Right Foot

Jose Altuve leads the Astros with 23 hits including 3 home runs and 7 RBIs. Jeremy Pena also has 3 homers and 4 stolen bases while Yordan Alvarez has 2 doubles and a team-high 10 RBIs with 15 strikeouts as well. Brendan Rodgers has a pair of doubles while Jake Meyers has a pair of doubles as well and Christian Walker has also accrued a team-high 23 strikeouts so far this season. Altuve also has 3 stolen bases while Jake Meyers has a team-high 6 stolen bases this season.

Why the Houston Astros will win

• The Padres have lost each of their last five games as road favorites against AL West opponents following a road loss.
• The Astros have won three of their last four games as underdogs after playing the previous day.
• The Padres have failed to cover the run line in each of their last seven games as road favorites against AL West opponents.
• The home team has covered the run line in each of the Padres’ last seven games.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in three of the Astros’ last four games against opponents that held a winning record.
• Yordan Alvarez has recorded at least one RBI in three of the Astros’ last four games against the Padres at Daikin Park.
• Jose Altuve has scored at least one run in seven of the Astros’ last eight home games against NL West opponents.
• Isaac Paredes has recorded at least one Single in 10 of his last 11 appearances with his team as an underdog against NL West opponents.
• Jose Altuve has recorded at least one hit in each of the Astros’ last 15 home games against NL West opponents.
• Jake Meyers ranks T2nd in the league in Steals (7) this season.

Total Runs Facts

• Each of the last seven games between the Padres and Astros at Daikin Park have gone OVER the total runs line.
• Six of the Padres’ last seven road games after playing the previous day have gone OVER the total runs line.

Astros vs Padres Prediction

I’m on the Padres here. The Padres fell flat in Friday’s opener, but Michael King might be the best option in this Padres’ rotation right now. I trust him more than I trust Hayden Wesneski, who for me has been a glorified spot starter for the better part of his career. He is not someone I’d want in the Astros’ starting rotation if I were an Astros fan. I think the Padres bounce back here and get the win at a nice price on the road in this game. Give me San Diego here.