Astros vs White Sox Prediction 6/11/25 MLB Picks Today

The Chicago White Sox and Houston Astros meet Wednesday in MLB action at Daikin Park. Here’s an Astros vs White Sox Prediction. This article will include an Astros vs White Sox Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 23-44 on the year and play the Rangers, Cardinals, and Blue Jays next. The Chicago White Sox are batting .222 on the season, have a .297 OBP, and a .344 slugging percentage. The Chicago White Sox pitching staff has a 4.09 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 55 hits and 17 RBI, while Miguel Vargas and Chase Meidroth have combined for 100 hits and 38 RBI.

Sean Burke gets the ball for the Chicago White Sox, and he is 3-6 with a 4.03 ERA and 50 strikeouts this season. This will be Burke’s first career game against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 36-30 on the year and play the Twins, Athletics, and Angels next. The Houston Astros are batting .251 on the season, have a .16 OBP, and a .385 slugging percentage. The Houston Astros’ pitching staff has a 3.53 ERA and a 1.17 WHIP. Jeremy Pena leads the Houston Astros with 81 hits and 32 RBI, while Jose Altuve and Jake Meyers have combined for 127 hits and 40 RBI.

Ryan Gusto gets the ball for the Houston Astros, and he is 3-3 with a 4.78 ERA and 45 strikeouts this season. This will be Gusto’s second career game against the Chicago White Sox.

Why the Houston Astros will win

• The White Sox have lost each of their last seven night games against American League opponents following a road win.
• The Astros have won each of their last seven home games following a home loss.
• The White Sox have failed to cover the run line in six of their last seven night games against American League opponents following a road win.
• The favorites have covered the run line in four of the Astros’ last five games.
• The Astros have led after 3 innings in three of their last four night games against American League opponents that held a losing record.
• The White Sox have trailed after 5 innings in six of their last eight road games against American League opponents that held a winning record.

Why the Chicago White Sox will win

• The White Sox have won four of their last five games as underdogs.
• The Astros have lost each of their last four night games against AL Central opponents that held a losing record.
• The White Sox have covered the run line in each of their last six games as underdogs against AL West opponents.
• The Astros have failed to cover the run line in eight of their last nine games as home favorites after playing the previous day.
• The Astros have trailed after 3 innings in six of their last seven home games against AL Central opponents.
• The Astros have trailed after 5 innings in each of their last seven home games against AL Central opponents.

Houston Astros Player Prop Facts

• Isaac Paredes has hit a home run in two of the Astros’ last three home games against AL Central opponents.
• Victor Caratini has recorded at least one hit in each of his last eight home appearances against opponents that held a losing record.
• Jeremy Pena has recorded at least one Double in each of the Astros’ last three games against opponents that held a losing record.
• Jeremy Pena has recorded at least one Single in each of the Astros’ last 14 games as favorites against AL Central opponents.
• Yordan Alvarez has recorded at least one RBI in 10 of his last 11 appearances with the Astros as favorites against the White Sox.
• Brendan Rodgers has scored at least one run in each of his five previous home appearances against AL Central opponents that held a losing record.
• Jeremy Pena ranks T3rd in the league in Hits (81) this season.

Chicago White Sox Player Prop Facts

• Luis Robert has hit at least one home run in four of the White Sox’s last six road games against AL West opponents that held a winning record.
• Luis Robert has recorded at least one RBI in each of the White Sox’s last four games against AL West opponents.
• Luis Robert has recorded at least one hit in each of his last 12 Wednesday night appearances against AL teams that held a winning record.
• Michael A. Taylor has scored at least one run in each of his last four appearances with the White Sox as underdogs.
• Mike Tauchman has recorded at least one Double in four of the White Sox’s last five road games.
• Austin Slater has recorded at least one Single in each of his last five appearances with his team as an underdog against the Astros.
• Luis Robert ranks T3rd in the league in Steals (21) this season.

Astros vs White Sox Prediction

The Astros should be favored for obvious reasons, and the White Sox are a team I’ve faded blindly over the years. However, this price is steep for Gusto, who has allowed 25 hits and 14 earned runs in his last 16.1 innings. The Astros have lost each of the last six games Gusto has pitched. The White Sox have quietly won games over the last week, and Burke has been sharp lately, allowing 32 hits and 12 earned runs in his last 40 innings. I don’t back the White Sox often, but this is a spot where there’s value. I’ll take a shot in the dark.