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Astros vs Yankees Prediction 4/25/26 MLB Picks Today

NY Yankees (17-9) vs. Houston Astros (10-17)
April 25, 2026 7:10 pm EDT
The Line: Houston Astros 0.0001 / NY Yankees 0.0001; Over/Under: 0.0001
(Get latest betting odds)

The New York Yankees and Houston Astros meet Saturday in MLB action at Daikin Park. Here’s an Astros vs. Yankees Prediction. This article will include an Astros vs. Yankees Pick.

New York Yankees Betting Preview

The New York Yankees are 17-9 on the year and play the Rangers and Orioles next. The New York Yankees are batting .229 on the season and have a .327 OBP, and a .422 slugging percentage. The New York Yankees pitching staff has a 3.11 ERA and a 1.12 WHIP. Ben Rice leads the New York Yankees with 25 hits and 20 RBI while Cody Bellinger and Jose Caballero have combined for 47 hits and 23 RBI.

Ryan Weathers gets the ball for the New York Yankees, and he is 1-2 with a 3.18 ERA and 36 strikeouts this season. This will be Weathers’ first career game against the Houston Astros.

Houston Astros Betting Preview

The Houston Astros are 10-17 on the year and play the Red Sox and Orioles next. The Houston Astros are batting. 261 on the season, have a .348 OBP, and have a .436 slugging percentage. The Houston Astros pitching staff has a 5.97 ERA and a 1.65 WHIP. Yordan Alvarez leads the Houston Astros with 35 hits and 26 RBI while Christian Walker and Jose Altuve have combined for 53 hits and 26 RBI.

Mike Burrows gets the ball for the Houston Astros, and he is 1-3 with a 6.75 ERA and 25 strikeouts this season. This will be Burrows’ second career game against the New York Yankees.

Why the Houston Astros will win

  • The Yankees have lost seven of their last eight games as favorites against AL West opponents following a win.
  • The Astros have won each of their last seven games against AL East opponents following a home loss.
  • The Astros have covered the run line in each of their last six games as underdogs against AL East opponents following a loss.
  • The Yankees have failed to cover the run line in seven of their last eight games as favorites against AL West opponents following a win.
  • The Astros have won the first inning in three of their last four home games against American League opponents.
  • The Astros have led after 3 innings in each of their last six Saturday night games against AL East opponents that held a winning record.
  • The Astros have led after 5 innings in four of their last five night games against AL East opponents.

Why the New York Yankees will win

  • The Yankees have won each of their last seven games.
  • The Astros have lost each of their last five home games.
  • The Yankees have covered the run line in each of their last seven games.
  • The Astros have failed to cover the run line in each of their last five home games.
  • The Astros have lost the first inning in four of their last five night games.
  • The Astros have trailed after 3 innings in nine of their last 10 night games against opponents that held a winning record.
  • The Yankees have led after 5 innings in each of their last six road games against AL West opponents that held a losing record.

Total Runs Facts

  • Each of the Astros’ last nine night games against American League opponents has gone OVER the total runs line.
  • Six of the Yankees’ last seven night games against American League opponents have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last 12 games as underdogs.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Yankees’ last five games against AL West opponents.

Houston Astros Player Prop Facts

  • Yordan Alvarez has hit a home run in three of the Astros’ last four home games.
  • Yordan Alvarez has recorded at least one hit in each of the Astros’ last 13 home games.
  • Yordan Alvarez ranks 1st in the league in Hits (35) this season.

New York Yankees Player Prop Facts

  • Jazz Chisholm has hit a home run in each of the Yankees’ last two games.
  • Paul Goldschmidt has recorded at least one hit in each of his last 10 road appearances against the Astros.
  • Ben Rice ranks 2nd amongst qualified players for Slugging Percentage (.747) this season.

Matchup/League Facts

  • The Astros rank 1st in the league for doubles this season (60).
  • The Astros rank 30th in the league for ERA this season (5.97).
  • The Yankees rank 1st in the league for ERA this season (3.11).
  • The Yankees rank 2nd in the league for home runs this season (39).

Astros vs Yankees Prediction

I don’t know how anybody backs the Astros with confidence with the way this pitching staff has looked all season. It’s a bad arm on a loop. Burrows falls into that boat with his 6.75 ERA And 1.69 WHIP through 26.2 innings. It’s not ideal when going up against a red-hot Yankees team that’s found their bats this week. There’s only one way to go into this spot. Give me the Yankees and the RL for max betting value.

Randy Chambers's Free Pick: NY Yankees -1.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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