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Athletics vs Padres Prediction 4/9/25 MLB Picks Today

San Diego Padres (9-3) vs. Athletics (5-7)
April 9, 2025 3:35 pm EDT
The Line: Athletics -115 / San Diego Padres -105; Over/Under: 9.5
(Get latest betting odds)

The San Diego Padres and Athletics meet on Wednesday in MLB action at Sutter Health Park. Here’s an Athletics vs Padres Prediction. This article will include an Athletics vs Padres Pick.

San Diego Padres Betting Preview

The San Diego Padres are 9-3 on the year and play the Rockies, Cubs, and Astros next. The San Diego Padres are batting .283 on the season, have a .348 OBP, and a .419 slugging percentage. The San Diego Padres’ pitching staff has a 3.51 ERA and a 1.22 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 16 hits and 7 RBI, while Luis Arraez and Manny Machado have combined for 30 hits and 9 RBI.


Randy Vasquez gets the ball for the San Diego Padres, and he is 0-1 with a 1.69 ERA and 5 strikeouts this season. This will be Vasquez’s second career game against the Athletics.

Athletics Betting Preview

The Athletics are 5-7 on the year and play the Mets, White Sox, and Brewers next. The Athletics are batting .252 in the season, have a .316 OBP, and a .428 slugging percentage. The Athletics’ pitching staff has a 5.38 ERA and a 1.55 WHIP. Jacob Wilson leads the Athletics with 18 hits and 7 RBI, while Tyler Soderstrom and Lawrence Butler have combined for 30 hits and 13 RBI.

Osvaldo Bido gets the ball for the Athletics, and he is 1-0 with a 2.70 ERA and 9 strikeouts this season. This will be Bido’s first career game against the San Diego Padres.

Why the Athletics will win

  • The home team has won 11 of the Padres’ last 13 games.
  • The Padres have lost six of their last seven games against AL West opponents following a road loss.
  • The Athletics have covered the run line in seven of their last eight games against NL West opponents that held a winning record.
  • The Padres have failed to cover the run line in each of their last five road games against American League opponents after playing the previous day.
  • The Padres have trailed after 3 innings in three of their last four games.
  • The Padres have trailed after 5 innings in each of their last four road day games.

Why the San Diego Padres will win

  • The Athletics have lost each of their last four games as favorites following a win.
  • The Padres have won each of their last six games against American League opponents following a loss.
  • The Padres have covered the run line in each of their last nine Wednesday games as road underdogs.
  • The Athletics have failed to cover the run line in each of their last six games as home favorites.
  • The Athletics have lost the first inning in four of their last five games as home favorites against NL West opponents.
  • The Athletics have trailed after 3 innings in eight of their last nine home games against National League opponents that held a winning record.
  • The Padres have led after 5 innings in nine of their last 10 games against the Athletics.

Matchup/League Facts

  • The Athletics rank 30th in the league for steals this season (2).
  • The Athletics rank 29th in the league for runs allowed this season (71).
  • The Padres rank 2nd in the league for batting average this season (.283).
  • The Padres rank 4th in the league for hits this season (112).

Athletics vs Padres Prediction

Give the Athletics credit for getting their first home win in their fifth try, but it doesn’t move the needle much in my eyes. The Athletics are watching their pitching staff get rocked nightly, and the Padres have the lineup to add to those bruises. Through 12 games, the Padres have been one of the best teams in the league, and Vazquez has been strong through two starts, despite the nine walks through 10.2 innings.

Once Vazquez improves his control, he’ll be somebody to watch in this rotation. The jury is still out on Bido through 20 career starts, but I have little trust in the Athletics overall based on what we’ve seen lately. Give me the Padres and the cheap price.

Randy Chambers's Free Pick: San Diego Padres -105

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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