Orioles vs Red Sox Prediction 8/25/25 MLB Picks Today

The Boston Red Sox and the Baltimore Orioles meet Monday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Orioles vs Red Sox Prediction.

Starting Pitching Matchup

The Boston Red Sox will send out Brennan Bernardino here and Bernardino is 4-2 with a 2.93 ERA and 38 strikeouts this season. This will be Bernardino’s second career start against the Orioles. Baltimore will start Tomoyuki Sugano here and Sugano is 10-5 with a 3.97 ERA and 85 strikeouts this season. This will be Sugano’s second career start against the Red Sox.

Boston Red Sox Recap

The Boston Red Sox come into this game looking to rebound from a 7-2 loss at the hands of the New York Yankees last time out to sit at 71-60 this season. After this series, the Red Sox will head home for a series against the Pittsburgh Pirates.

Red Sox Have Three-Game Win Streak Snapped

Alex Bregman has 96 hits including 24 doubles along with 16 home runs and 53 RBIs this season. Trevor Story’s added 127 hits with 20 home runs, 82 RBIs and 22 stolen bases while Jarren Duran has 131 hits with 34 doubles, 12 triples, 12 home runs, 70 RBIs and a team-high 21 stolen bases. Kristian Campbell’s added 51 hits with 10 doubles, 6 homers and 21 RBIs while Wilyer Abreu has 22 home runs with 69 RBIs and 6 stolen bases and Ceddanne Rafaela has 14 homers, 26 doubles, 3 triples, 53 RBIs and 19 stolen bases this season.

Why the Boston Red Sox will win

• The Red Sox have won each of their last six night games against the Orioles at Oriole Park at Camden Yards following a road loss.
• The Orioles have lost five of their last six games against the Red Sox following a home win.
• The road team has covered the run line in each of the Orioles’ last nine games.
• The Orioles have failed to cover the run line each of their last four games against teams that held a winning record.

Boston Red Sox Player Prop Facts

• Trevor Story has hit a home run in three of the Red Sox’s last four road games against opponents that held a losing record.
• Jarren Duran has recorded a Double in each of the Red Sox’s last four road games against opponents that held a losing record.
• Masataka Yoshida has recorded at least one hit in each of his last eight appearances against the Orioles after playing the previous day.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to build on their 3-2 win over Houston last time out to sit at 60-70 this season. After this series, the Orioles will head on the road for a series against the San Francisco Giants.

Orioles Snap Three-Game Skid

Adley Rutschman has 70 hits with 16 doubles, 9 homers and 29 RBIs. Jackson Holliday has 118 hits with 17 doubles, 2 triples, 15 homers and 49 RBIs. Gunnar Henderson has 128 hits with 29 doubles, 5 triples, 15 home runs and 57 RBIs with 16 stolen bases and 112 strikeouts while Holliday has a team-high 116 strikeouts as well this season. Heston Kjerstad’s added 4 homers and 19 RBIs while Jordan Westburg has 15 home runs and 34 RBIs this season.

Why the Baltimore Orioles will win

• The underdogs have won each of the last five games between the Red Sox and Orioles.
• The Red Sox have lost each of their last six Monday games as road favorites.
• The underdogs have covered the run line in 15 of the Orioles’ last 16 games.
• The Red Sox have failed to cover the run line each of their last five night games against AL East opponents that held a losing record.

Baltimore Orioles Player Prop Facts

• Gunnar Henderson has hit a home run in four of his last five home appearances against the Red Sox.
• Gunnar Henderson has recorded a Double in four of the Orioles’ last five games as home underdogs against AL opponents.
• Gunnar Henderson has recorded at least one hit in each of the Orioles’ last 13 home games.

Total Runs Facts

• Nine of the Red Sox’s last 10 games as favorites against American League opponents have gone OVER the total runs line.
• Five of the Orioles’ last six night games against American League opponents have gone OVER the total runs line.

Orioles vs Red Sox Prediction

I’m on the Orioles in this one. I just like the form that Sugano is in, and the Orioles looked solid in Sunday’s finale against Houston. Boston’s coming in off of a Sunday night game against the Yankees, and I’m not a big Bernardino fan or a fan of this Red Sox bullpen right now. I think the Orioles are showing some value at home, so give me Baltimore here.