Pirates vs Cardinals Prediction 8/25/25 MLB Picks Today

In this article, we will formulate a Pirates vs Cardinals Prediction for this MLB game on Monday, August 25^th at the Busch Stadium in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 64-67 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 30-35 home record and are 66-57 in over/under They are coming off a 2-7 road defeat by the Rays, and are 1-3 in their last 4 games. Over is 6-0-2 in their last 6 games and are playing the Athletics and the Reds next.

The Cardinals have a .249 batting average this season, .317 OBP and .385 Slugging percentage. Saint Louis’ pitching staff has a 4.31 ERA and 1.31 WHIP. Brendan Donovan leads the Cardinals with 118 hits, while Alec Burleson is the team’s best hitter with a .285 batting average. Wilson Contreras leads the team in RBI, with 70, adding a team-high 19 home runs.

Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 5-2 record, 4.26 ERA and 1.18 WHIP.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 57-74 record this season and are sitting on the last place of the NL Central. They have a 18-44 road record, and are 53-73 in over/under. They are coming off a 4-0 home victory over the Rockies, and have four consecutive wins. Under is 3-1 in their last 4 games and are playing the Red Sox and the Dodgers next.

The Pirates have a .234 batting average this season, .305 OBP and .351 slugging percentage. Pittsburgh’s pitching staff has a 3.93 ERA and 1.22 WHIP. Bryan Reynolds leads the Pirates with 118 hits, and a team-high 63 RBI. Isiah Kiner-Falefa is the team’s best hitter with a .265 batting average, while Oneil Cruz leads the team in home runs, with 18.

Johan Oviedo (R) is the projected starting pitcher for the Pirates, and he has a 1-0 record, 4.50 ERA and 1.33 WHIP.

Why the St. Louis Cardinals will win

• The Pirates have lost each of their last seven road games against the Cardinals following a home win.
• The home team has won each of the last seven games between the Pirates and Cardinals.
• The Cardinals have covered the run line in each of their last nine night games following a road loss.
• The Pirates have failed to cover the run line each of their last eight games at Busch Stadium against teams that held a losing record.
• The Cardinals have led after 3 innings in four of their last five games as home favorites against NL Central opponents.
• The Cardinals have led after 5 innings in five of their last six games as home favorites against NL Central opponents.

Why the Pittsburgh Pirates will win

• The Cardinals have lost four of their last five games as home favorites.
• The Pirates have won four of their last six games as underdogs against the Cardinals.
• The Cardinals have failed to cover the run line in each of their last seven games as favorites against NL Central opponents following a road loss.
• The Pirates have covered the run line in each of their last seven games as underdogs against NL Central opponents following a home win.
• The Pirates have led after 5 innings in eight of their last nine games against National League opponents that held a losing record.
• The Pirates have won the first inning in each of their last three road games against National League opponents that held a losing record.
• The Pirates have led after 3 innings in each of their last four road games against National League opponents that held a losing record.

Total Runs Facts

• Seven of the Cardinals’ last eight games after playing the previous day have gone OVER the total runs line.
• Each of the Pirates’ last three games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the Pirates’ last 13 games at Busch Stadium.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last six games as home favorites.

Matchup/League Facts

• The Cardinals rank 30th in the league for triples this season (5).
• The Cardinals rank 29th in the league for strikeouts this season (960).
• The Pirates rank 30th in the league for runs scored this season (467).
• The Pirates rank 30th in the league for home runs this season (94).

Pirates vs Cardinals Prediction

The Pirates have won their last three head-to-head meetings against the Cardinals, but the Cardinals have won their last three meetings in Saint Louis. Over is 5-0 in their last 5 meetings.

In this Pirates vs Cardinals Prediction, the Cardinals are coming as -140 home favorites. I don’t trust either pitcher in this matchup, as they have both been shaky at best, and are not coming into this matchup in their best form possible. I cannot make a case for the Pirates on the road, as they have been terrible away from Pittsburgh, they have a weaker bullpen and are also dead last in the league in runs scored. I expect the home team to get the job done in this one, so take the Saint Louis Cardinals on the moneyline.