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Orioles vs Twins Prediction 3/28/26 MLB Picks Today

Minnesota Twins (0-1) vs. Baltimore Orioles (1-0)
March 28, 2026 4:05 pm EDT
The Line: Baltimore Orioles -163 / Minnesota Twins +135; Over/Under: 7.5
(Get latest betting odds)

The Minnesota Twins and the Baltimore Orioles meet Saturday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Orioles vs. Twins Prediction.

Starting Pitching Matchup

The Minnesota Twins will start Taj Bradley here and Bradley was 6-8 with a 5.05 ERA and 127 strikeouts last season. In his last five starts against Baltimore, Bradley is 1-3 with a 9.00 ERA and 20 strikeouts. Kyle Bradish will start for the Orioles here and was 1-1 with a 2.53 ERA and 47 strikeouts last season. In his career, Bradish is 0-1 with a 4.50 ERA and 10 strikeouts against Minnesota.

Minnesota Twins Recap

The Minnesota Twins come into this game off of their 2-1 loss at the hands of the Orioles in Thursday’s matchup. After this series, the Twins will head on the road for a game against the Kansas City Royals.

Twins Looking To Avoid Series Loss In Opener

Luke Keaschall had the lone RBI for the Twins while Byron Buxton added a triple. Austin Martin, Ryan Jeffers and Victor Caratini each had a base hit as well in the losing effort for the Twins. Joe Ryan gave up one hit over 5.1 innings of shutout baseball with 7 strikeouts, but it was Kody Funderburk that took the loss to start the year at 0-1.

Why the Minnesota Twins will win

  • The Orioles have lost each of their last nine Saturday games against American League opponents.
  • The Twins have won three of their last four games as underdogs against the Orioles.
  • The Orioles have failed to cover the run line in each of their last 11 games as home favorites.
  • The Twins have covered the run line in each of their last seven games against the Orioles.

Minnesota Twins Player Prop Facts

  • Byron Buxton has hit at least one home run in three of his last four appearances against opponents that held a winning record.
  • Ryan Jeffers has recorded at least one hit in 15 of his last 16 appearances after not playing the previous day.
  • Byron Buxton ranked 6th amongst qualified players for Slugging Percentage (.551) last season.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to add on to their season-opening win over the Twins from their last matchup to start the year at 1-0. After this series, the Orioles will take on the Texas Rangers at home.

Orioles Looking For Series Win Out Of The Gate

Blaze Alexander and Colton Cowser accounted for the lone RBIs for Baltimore in the win, while Adley Rutschman added a 2 for 4 day with a double and Samuel Basallo and Tyler O’Neill each had a base hit as well in the victory. Trevor Rogers got the win after throwing seven innings of three-hit shutout baseball with five strikeouts. Ryan Helsley closed out the 9th for the save.

Why the Baltimore Orioles will win

  • The Twins have lost each of their last nine games against the Orioles following a loss.
  • The Orioles have won each of their last six day games against AL Central opponents.
  • The Orioles have covered the run line in each of their last six games against the Twins following a home win.
  • The Twins have failed to cover the run line in eight of their last nine games against the Orioles following a loss.

Baltimore Orioles Player Prop Facts

  • Pete Alonso has hit at least one home run in three of his last four home appearances after not playing the previous day.
  • Kyle Bradish has recorded eight or more strikeouts in each of his last five appearances against AL opponents.
  • Kyle Bradish has recorded a win in three of his last four appearances with the Orioles as favorites against AL opponents.
  • Ryan Mountcastle has recorded at least one hit in each of his last 17 appearances against the Twins.
  • Ryan Mountcastle has recorded a Double in three of his last four appearances against the Twins.
  • Pete Alonso ranked 8th in the league in Home Runs (38) last season.

Total Runs Facts

  • Each of the Twins’ last 10 games has gone UNDER the total runs line.
  • Each of the Orioles’ last seven-day games against AL Central opponents have gone UNDER the total runs line.

Orioles vs Twins Prediction

I’m in Baltimore here. I just don’t love the matchup here for Taj Bradley, as he’s historically had some major issues dealing with Baltimore from his time in Tampa Bay. The Orioles are looking improved from an already talented lineup that was just injured last year, but I think they’re going to be a team to watch and it started from the opening pitch. Give me Baltimore.

Chris Ruffolo's Free Pick: Baltimore Orioles -163

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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